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The human histaminergic system in neuropsychiatric disordersShan, Ling ; Bao, Ai-Min ; Swaab, Dick FransHistaminergic neurons are exclusively located in the hypothalamic tuberomamillary nucleus, from where they project to many brain areas. The histaminergic system is involved in basic physiological ... functions, such as the sleep-wake cycle, energy and endocrine homeostasis, sensory and motor functions, cognition, and attention, which are all severely affected in neuropsychiatric disorders. Here, we present recent postmortem findings on the alterations in this system in neuropsychiatric disorders, including Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), depression, and narcolepsy. In addition, we highlight the need to validate animal models for these diseases and also for Tourette's syndrome (TS) in relation to alterations in the histaminergic system. Moreover, we discuss the potential for, and concerns over, the use of novel histamine 3 receptor (H3R) antagonists/inverse agonists as treatment for such disorders.Source: Trends in Neurosciences. - ISSN 0166-2236 (Vol. 38, no. 3, Mar. 2015, str. 167-177)Type of material - article, component partPublish date - 2015Language - englishCOBISS.SI-ID - 34074585
Author
Shan, Ling |
Bao, Ai-Min |
Swaab, Dick Frans
Topics
Parkinson's disease |
Alzheimer's disease |
narcolepsy |
Parkinsonova bolezen |
Alzheimerjeva bolezen |
narkolepsija
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Shan, Ling | ![]() |
Bao, Ai-Min | ![]() |
Swaab, Dick Frans | 52101 |
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