-
Focus on ulcerative colitis : stable gastric pentadecapeptide BPC 157Sikirić, Predrag ...Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects. BPC ... 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD) (PL 14736) so far only tested in clinical phase II, has a very safe profile, and exhibited a particular wound healing effect. It also has shown to interact with the NO-system, providing endothelium protection and angiogenic effect, even in severely impaired conditions (i.e., it stimulated expression of early growth response 1 gene responsible for cytokine and growth factor generation and early extracellular matrix (collagen) formation (but also its repressor nerve growth factor 1- A binding protein-2)), important to counteract severe complications of advanced and poorly controlled IBD. Hopefully, the lessons from animal studies, particularly advanced intestinal anastomosis healing, reversed short bowel syndrome and fistula healing indicate BPC 157s high significance in further IBD therapy. Also, this supportive evidence (i.e., no toxic effect, limit test negative, LD1 not achieved, no side effect in trials) may counteract the problems commonly exercised in the use of peptidergic agents, particularly those used on a long-term basis.Source: Current medicinal chemistry. - ISSN 0929-8673 (iss. 1, Vol. 19, 2012, str. 126-132)Type of material - article, component part ; adult, seriousPublish date - 2012Language - englishCOBISS.SI-ID - 34197465
Author
Sikirić, Predrag |
Seiwerth, Sven |
Ručman, Rudolf, 1940- |
Turkovic, Branko |
Stančić-Rokotov, Dinko |
Brčić, Luka |
Sever, Marko, 1981- |
Klicek, Robert |
Radic, Bozo |
Kolenc, Danijela
Topics
BPC 157 |
intestinal anastomosis |
inflammatory bowel disease |
BPC 157 |
intestinalna anastomoza |
vnetna črevesna bolezen
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Sikirić, Predrag | |
Seiwerth, Sven | |
Ručman, Rudolf, 1940- | 09952 |
Turkovic, Branko | |
Stančić-Rokotov, Dinko | |
Brčić, Luka | |
Sever, Marko, 1981- | |
Klicek, Robert | |
Radic, Bozo | |
Kolenc, Danijela | 52857 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.