-
Therapy for unhealed gastrocutaneous fistulas in ratsas a model for analogous healing of persistent skin woundsand persistent gastric ulcers : stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazoleŠkorjanec, Sandra, zdravnica ...Objective This study focused on unhealed gastrocutaneous fistulas to resolve whether standard drugs that promote healing of gastric ulcers may simultaneously have the same effect on cutaneous wounds, ... and corticosteroid aggravation, and to demonstrate why peptides such as BPC 157 exhibit a greater healing effect. Therefore, with the fistulas therapy, we challenge the wound/growth factors theory of the analogous nonhealing of wounds and persistent gastric ulcers. Methods The healing rate of gastrocutaneous fistula in rat (2-mm-diameter stomach defect, 3-mm-diameter skin defect) validates macro/microscopically and biomechanically a direct skin wound/stomach ulcer relation, and identifies a potential therapy consisting of: (i) stable gastric pentadecapeptide BPC 157 [in drinking water (10 [micro]g/kg) (12 ml/rat/day) or intraperitoneally (10 [micro]g/kg, 10 ng/kg, 10 pg/kg)], (ii) atropine (10 mg/kg), ranitidine (50 mg/kg), and omeprazole (50 mg/kg), (iii) 6-alpha-methylprednisolone (1 mg/kg) [intraperitoneally, once daily, first application at 30 min following surgery; last 24 h before sacrifice (at postoperative days 1, 2, 3, 7, 14, and 21)]. Results Greater anti-ulcer potential and efficiency in wound healing compared with standard agents favor BPC 157, efficient in inflammatory bowel disease (PL-14736, Pliva), given in drinking water or intraperitoneally. Even after 6-alpha-methylprednisolone aggravation, BPC 157 promptly improves both skin and stomach mucosa healing, and closure of fistulas, with no leakage after up to 20 ml water intragastrically. Standard anti-ulcer agents, after a delay, improve firstly skin healing and then stomach mucosal healing, but not fistula leaking and bursting strength (except for atropine). Conclusion We conclude that BPC 157 may resolve analogous nonhealing of wounds and persistent gastric ulcers better than standard agents.Source: Digestive diseases and sciences. - ISSN 0163-2116 (Vol. 54, no. 1, 2009, str. 46-56)Type of material - article, component part ; adult, seriousPublish date - 2009Language - englishCOBISS.SI-ID - 34216665
Author
Škorjanec, Sandra, zdravnica |
Dolovski, Zdravko |
Kocman, Ivan |
Brčić, Luka |
Boban Blagaic, Alenka |
Batelja, Lovorka |
Coric, Marjana |
Sever, Marko, 1981- |
Klicek, Robert |
Kolenc, Danijela
Topics
želodčni pentadekapeptid BPC 157 |
unhealed gastrocutaneous fistulas |
persistent gastric ulcer |
gastric pentadecapeptide BPC 157 |
nezdravljene gastro-kožne fistule |
vztrajna razjeda želodca
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Škorjanec, Sandra, zdravnica | |
Dolovski, Zdravko | |
Kocman, Ivan | |
Brčić, Luka | |
Boban Blagaic, Alenka | |
Batelja, Lovorka | |
Coric, Marjana | |
Sever, Marko, 1981- | |
Klicek, Robert | |
Kolenc, Danijela | 52857 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.