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Stable gastric pentadecapeptide BPC 157 in the therapy of the rats with bile duct ligationZenko Sever, Anita ...Recently, stable gastric pentadecapeptide BPC 157 reversed the high MDA- and NO-tissue values to the healthy levels. Thereby, BPC 157 therapy cured rats with bile duct ligation (BDL) (sacrifice at 2, ... 4, 6, 8 week). BPC 157-medication (10[micro]g/kg, 10 ng/kg) was continuously in drinking water (0.16[micro]g/ml, 0.16ng/ml, 12 ml/rat/day) since awakening from surgery, or since week 4. Intraperitoneal administration was first at 30 min post-ligation, last at 24h before sacrifice. Local bath BPC 157 (10[micro]g/kg) with assessed immediate normalization of portal hypertension was given immediately after establishing portal hypertension values at 4, 6, 8 week. BPC 157 therapy markedly abated jaundice, snout, ears, paws, and yellow abdominal tegmentum in controls since 4th week, ascites, nodular, steatotic liver with large dilatation of main bile duct, increased liver and/or cyst weight, decreased body weight. BPC 157 counteracts the piecemeal necrosis, focal lytic necrosis, apoptosis and focal inflammation, disturbed cell proliferation (Ki-67-staining), cytoskeletal structure in the hepatic stellate cell ([alpha]-SMA staining), collagen presentation (Mallory staining). Likewise, counteraction includes increased AST, ALT, GGT, ALP, total bilirubin, direct and indirect and decreased albumin serum levels. As the end-result appear normalized MDA- and NO-tissue values, next to Western blot of NOS2 and NOS3 in the liver tissue, and decreased IL-6, TNF-[alpha], IL-1[beta] levels in liver tissue. Finally, although portal hypertension is sustained in BDL-rats, with BPC 157 therapy, portal hypertension in BDL-rats is either not even developed or rapidly abated, depending on the given BPC 157's regimen. Thus, BPC 157 may counteract liver fibrosis and portal hypertension.Source: European Journal of Pharmacology. - ISSN 0014-2999 (Vol. 847, Mar. 2019, str. 130-142)Type of material - article, component partPublish date - 2019Language - englishCOBISS.SI-ID - 34219993
Author
Zenko Sever, Anita |
Sever, Marko, 1981- |
Vidovic, Tinka |
Lojo, Nermin |
Kolenc, Danijela |
Batelja Vuletic, Lovorka |
Drmić, Domagoj |
Kokot, Antonio, farmacija |
Zoricic, Ivan |
Coric, Marijana
Topics
pentadecapeptide BPC 157 |
liver fibrosis/cirrhosis |
portal hypertension |
pentadekapeptid BPC 157 |
fibroza / ciroza jeter |
portalna hipertenzija
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Zenko Sever, Anita | |
Sever, Marko, 1981- | |
Vidovic, Tinka | |
Lojo, Nermin | |
Kolenc, Danijela | 52857 |
Batelja Vuletic, Lovorka | |
Drmić, Domagoj | |
Kokot, Antonio, farmacija | |
Zoricic, Ivan | |
Coric, Marijana |
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