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FAM19A4/miR124-2 methylation in invasive cervical cancer : a retrospective cross-sectional worldwide studyVink, Frederique J. ...Widespread adoption of primary human papillomavirus (HPV)-based screening has encouraged the search for a triage test which retains high sensitivity for the detection of cervical cancer and ... precancer, but increases specificity to avoid overtreatment. Methylation analysis of FAM19A4 and miR124-2 genes has shown promise for the triage of high-risk (hr) HPV-positive women. In our study, we assessed the consistency of FAM19A4/miR124-2 methylation analysis in the detection of cervical cancer in a series of 519 invasive cervical carcinomas (n = 314 cervical scrapes, n = 205 tissue specimens) from over 25 countries, using a quantitative methylation-specific PCR (qMSP)-based assay (QIAsure Methylation Test%). Positivity rates stratified per histotype, FIGO stage, hrHPV status, hrHPV genotype, sample type and geographical region were calculated. In total, 510 of the 519 cervical carcinomas (98.3%; 95% CI: 96.7-99.2) tested FAM19A4/miR124-2 methylation-positive. Test positivity was consistent across the different subgroups based on cervical cancer histotype, FIGO stage, hrHPV status, hrHPV genotype, sample type and geographical region. In conclusion, FAM19A4/miR124-2 methylation analysis detects nearly all cervical carcinomas, including rare histotypes and hrHPV-negative carcinomas. These results indicate that a negative FAM19A4/miR124-2 methylation assay result is likely to rule out the presence of cervical cancer.Source: International journal of cancer = Journal international du cancer. - ISSN 0020-7136 (Vol. 147, iss. 4, Aug. 2020, str. 1215-1221)Type of material - article, component part ; adult, seriousPublish date - 2020Language - englishCOBISS.SI-ID - 34532057
Author
Vink, Frederique J. |
Meijer, Chris J.L.M. |
Clifford, Gary M. |
Poljak, Mario, 1965- |
Oštrbenk Valenčak, Anja |
Petry, Karl Ulrich |
Rothe, Beate |
Bonde, Jesper |
Pedersen, Helle |
de Sanjosé, Silvia
Topics
DNA hypermethylation |
biomarker |
cervical carcinoma |
hipermetilacija DNA |
biomarker |
rak materničnega vratu
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Vink, Frederique J. | |
Meijer, Chris J.L.M. | |
Clifford, Gary M. | |
Poljak, Mario, 1965- | 11622 |
Oštrbenk Valenčak, Anja | 35359 |
Petry, Karl Ulrich | |
Rothe, Beate | |
Bonde, Jesper | |
Pedersen, Helle | |
de Sanjosé, Silvia |
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