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  • Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia [Elektronski vir]
    Oroz, Maja ...
    Molecular epidemiology of HIV-1 infection in treatment-naive HIV-1 infected persons from Croatia was investigated. We included 403 persons, representing 92.4% of all HIV-positive individuals entering ... clinical care in Croatia in 2014%2017. Overall prevalence of transmitted drug resistance (TDR) was estimated at 16.4%. Resistance to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside RTI (NNRTIs) and protease inhibitors (PIs) was found in 11.4%, 6.7% and 2.5% of persons, respectively. Triple-class resistance was determined in 2.2% of individuals. In addition, a single case (1.0%) of resistance to integrase strand-transfer inhibitors (InSTIs) was found. Deep sequencing was performed on 48 randomly selected samples and detected additional TDR mutations in 6 cases. Phylogenetic inference showed that 347/403 sequences (86.1%) were part of transmission clusters and identified forward transmission of resistance in Croatia, even that of triple-class resistance. The largest TDR cluster of 53 persons with T215S was estimated to originate in the year 1992. Our data show a continuing need for pre-treatment HIV resistance testing in Croatia. Even though a low prevalence of resistance to InSTI was observed, surveillance of TDR to InSTI should be continued.
    Source: Scientific reports [Elektronski vir]. - ISSN 2045-2322 (Vol. 9, iss. 1, Nov. 2019, str. 1-14)
    Type of material - e-article ; adult, serious
    Publish date - 2019
    Language - english
    COBISS.SI-ID - 34625497

    Link(s):

    https://www.nature.com/articles/s41598-019-53520-8.pdf
    DOI

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