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  • Experimental and numerical study of electroporation induced by long monopolar and short bipolar pulses on realistic 3D irregularly shaped cells
    Chiapperino, Michele Alessandro ...
    In this paper, the effects of irreversible electroporation induced by rectangular long unipolar and short bipolar voltage pulses on 3D cells have been illustrated. The cells geometry was ... reconstructed starting from 3D images of real cells obtained using the confocal microscopy technique. A numerical model based on the Maxwell and the asymptotic Smoluchowski equations has been developed to calculate the induced transmembrane voltage and pore density on the plasma membrane of the real cells exposed to the pulsed electric field. Moreover, in the case of the high-frequency pulses, the dielectric dispersion of plasma membranes has been taken into account using the second-order Debye-based relationship. Several numerical simulations have been performed obtaining a good agreement between the numerical and experimental results.
    Source: IEEE transactions on bio-medical engineering. - ISSN 0018-9294 (Vol. 67, no. 10, Oct. 2020, str. 2781-2788)
    Type of material - article, component part
    Publish date - 2020
    Language - english
    COBISS.SI-ID - 3484283

    Link(s):

    https://ieeexplore.ieee.org/document/8979152
    DOI

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