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Vloga označevalcev vnetja pri levkoaraiozi = The role of inflammatory markers in leukoaraiosis [El. vir]Jerin, Aleš ; Zupan, Matija, dr. med., 1981- ; Skitek, MilanDifuzne spremembe bele možganovine so povezane z zvečano možnostjo za razvoj demence in upad kognitivnih sposobnosti, ter tudi z zvečanim tveganjem za možgansko kap. Kljub velikemu kliničnemu pomenu ... tega stanja pa patofiziologija levkoaraioze še ni povsem jasna. K patološkim spremembam prispeva endotelijska disfunkcija ter posledično hipoksija, ki vpliva tudi na sproščanje vnetnih dejavnikov. Dodaten prispevek k patologiji je tudi okvara krvno-možganske bariere, ki olajša prehod snovi, zvečano prehajanje vnetnih dejavnikov pa dodatno intenzivira vnetne procese. Označevalci vnetja in označevalci funkcije endotelija bi lahko imeli pomembno vlogo pri spremljanju bolezni. Pri bolnikih z levkoaraiozo so poleg zvišanja ugotovili tudi povezavo med koncentracijo CRP in IL-6 v obtoku in obsežnostjo difuznih sprememb bele možganovine. V nekaterih raziskavah so ugotovili le povezavo vnetnih dejavnikov z zmanjšanjem volumna možganskega tkiva, niso pa potrdili povezave z difuznimi spremembami bele možganovine. Neskladnost ugotovitev dosedanjih raziskav je posledica različne zasnove raziskav, vloga vnetnih dejavnikov pri difuznih spremembah bele možganovine zato še ni povsem razjasnjena.Source: 6. Jesenovčevi dnevi - raziskovalni dnevi laboratorijske biomedicine, 20. september 2014, Ljubljana [Elektronski vir] : zbornik predavanj (Str. 48-54)Type of material - conference contributionPublish date - 2014Language - slovenianCOBISS.SI-ID - 3713905
Author
Jerin, Aleš |
Zupan, Matija, dr. med., 1981- |
Skitek, Milan
Topics
levkoaraioza |
označevalci vnetja |
možganovina
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DRS, in which the journal is indexed
| Database name | Field | Year |
|---|
| Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
|---|---|
| Jerin, Aleš | 17160 |
| Zupan, Matija, dr. med., 1981- | 32226 |
| Skitek, Milan | 11331 |
Source: Personal bibliographies
and: SICRIS
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