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Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells [Elektronski vir]Perišić, Milica ...Cysteine cathepsins are lysosomal peptidases involved at different levels in the processes of the innate and adaptive immune responses. Some, such as cathepsins B, L, and H are expressed ... constitutively in most immune cells. In cells of innate immunity they play a role in cell adhesion and phagocytosis. Other cysteine cathepsins are expressed more specifically. Cathepsin X promotes dendritic cell maturation, adhesion of macrophages, and migration of T cells. Cathepsin S is implicated in major histocompatibility complex class II antigen presentation, whereas cathepsin C, expressed in cytotoxic T lymphocytes and natural killer (NK) cells, is involved in processing pro-granzymes into proteolytically active forms, which trigger cell death in their target cells. The activity of cysteine cathepsins is controlled by endogenous cystatins, cysteine protease inhibitors. Of these, cystatin F is the only cystatin that is localized in endosomal/lysosomal vesicles. After proteolytic removal of its N-terminal peptide, cystatin F becomes a potent inhibitor of cathepsin C with the potential to regulate pro-granzyme processing and cell cytotoxicity. This review is focused on the role of cysteine cathepsins and their inhibitors in the molecular mechanisms leading to the cytotoxic activity of T lymphocytes and NK cells in order to address new possibilities for regulation of their function in pathological processes.Source: Frontiers in immunology. - ISSN 1664-3224 (Vol. 5, 2014, art. 616)Type of material - e-articlePublish date - 2014Language - englishCOBISS.SI-ID - 3788913
Author
Perišić, Milica |
Sabotič, Jerica |
Jewett, Anahid |
Kos, Janko, 1959-
Topics
katepsini |
cisteini |
citotoksičnost |
citotoksične T celice |
naravne celice ubijalke
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Perišić, Milica | 36596 |
Sabotič, Jerica | 23576 |
Jewett, Anahid | ![]() |
Kos, Janko, 1959- | 04648 |
Source: Personal bibliographies
and: SICRIS
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