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Polielektrolitni kompleksi kot osnova za razvoj novih nanodelcev in nanooblog = Polyelectrolyte complexes as a platform for development of novel nanoparticles and nanocoatingsMirtič, Janja, farmacevtka ...Nastanek polielektrolitnih kompleksov temelji na ionskih interakcijah med ioniziranim polimerom (polielektrolitom) in spojino z nasprotnim nabojem, ki je lahko polimer, protein, površinsko aktivna ... snov oziroma katera koli spojina z nabojem. Zdravilne učinkovine lahko spadajo v katero od naštetih kategorij in se v te komplekse vgradijo na osnovi ionskih interakcij, lahko pa so vgrajene preprosto z mehanskim ujetjem med nastankom kompleksa. Nastanek polielektrolitnih kompleksov je spontan, vendar je treba pri oblikovanju upoštevati številne dejavnike, med katerimi je najpomembnejše prav razmerje nabojev ioniziranih skupin, ki odločilno vpliva na koloidno stabilnost nastalih kompleksov. Za ugotavljanje mehanizma kompleksiranja in vrednotenje nastalih kompleksov so znane številne metode. Polielektrolitni kompleksi so pogosto predmet raziskav in uporabe predvsem kot funkcionalni polimerni dostavni sistemi učinkovin. Pri zadnjih so v ospredju predvsem nanodostavni sistemi, kjer so polielektrolitni kompleksi osnova za njihov nastanek ter omogočajo prirejeno sproščanje učinkovin, njihovo zaščito pred razgradnjo in ciljano dostavo.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 67, št. 4, 2016, str. 310-317)Type of material - article, component partPublish date - 2016Language - slovenianCOBISS.SI-ID - 4103281
source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 67, št. 4, 2016, str. 310-317)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Mirtič, Janja, farmacevtka | 39199 |
Kogej, Ksenija | 04614 |
Gašperlin, Mirjana | 11789 |
Lapanje, Aleš | 21408 |
Kristl, Julijana | 09032 |
Source: Personal bibliographies
and: SICRIS
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