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Phage display peptide libraries in molecular allergology : from epitope mapping to mimotope-based immunotherapyLuzar, Jernej, farmacevt ; Štrukelj, Borut ; Lunder, Mojca, 1977-Identification of allergen epitopes is a key component in proper understanding of the pathogenesis of type I allergies, for understanding cross-reactivity and for the development of mimotope ... immunotherapeutics. Phage particles have garnered recognition in the field of molecular allergology due to their value not only in competitive immunoscreening of peptide libraries but also as immunogenic carri- ers of allergen mimotopes. They integrate epitope discovery technology and immunization functions into a single platform. This article provides an overview of allergen mimotopes identified through the phage display technique. We discuss the contribution of phage display peptide libraries in determining dominant B-cell epitopes of allergens, in developing mimotope immunotherapy, in understanding cross-reactivity, and in determining IgE epitope profiles of individual patients to improve diagnostics and individualize immunotherapy. We also discuss the advantages and pitfalls of the methodology used to identify and validate the mimotopes.Source: Allergy. - ISSN 0105-4538 (Vol. 71, iss. 11, 2016, str. 1526-1532)Type of material - article, component partPublish date - 2016Language - englishCOBISS.SI-ID - 4144497
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http://onlinelibrary.wiley.com/doi/10.1111/all.12965/abstract?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+3rd+September+2016+at+08.30+BST%2F+03%3A30+EDT%2F+15%3A30+SGT+for+5+hours+and+Sunday+4th+September+at+10%3A00+BST%2F+05%3A00+EST%2F+17%3A00+SGT+for+1+hour++for+essential+maintenance.+Apologies+for+the+inconvenience
http://onlinelibrary.wiley.com/doi/10.1111/all.12965/pdf
DOI
Author
Luzar, Jernej, farmacevt |
Štrukelj, Borut |
Lunder, Mojca, 1977-
Topics
immunotherapy |
mimotopes |
phage display |
peptide libraries |
allergen epitopes
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Luzar, Jernej, farmacevt | 35434 |
Štrukelj, Borut | 07849 |
Lunder, Mojca, 1977- | 25096 |
Source: Personal bibliographies
and: SICRIS
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