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A new 'golden age' for the antitubercular target InhARožman, Kaja, farmacevtka ...The increasing prevalence of multidrug-resistant strains of Mycobacterium tuberculosis is the main contributing factor in unfavorable outcomes in the treatment of tuberculosis. Studies suggest that ... direct inhibitors of InhA, an enoyl-ACP-reductase, might yield promising clinical candidates that can be developed into new antitubercular drugs. In this review, we describe the application of different hit-identification strategies to InhA, which clearly illustrate the druggability of its active site through distinct binding mechanisms. We further characterize four classes of InhA inhibitors that show novel binding modes, and provide evidence of their successful target engagement as well as their in vivo activity.Source: Drug discovery today. - ISSN 1359-6446 (Vol. 22, iss. 3, Mar. 2017, str. 492-502)Type of material - article, component part ; adult, seriousPublish date - 2017Language - englishCOBISS.SI-ID - 4168305
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Rožman, Kaja, farmacevtka | 37050 |
Sosič, Izidor | 30816 |
Fernandez-Menendez, Raquel | ![]() |
Young, Robert J., chemist | ![]() |
Mendoza-Losana, Alfonso | ![]() |
Gobec, Stanislav, 1970- | 15284 |
Encinas, Lourdes | ![]() |
Source: Personal bibliographies
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