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  • Human cathepsin X/Z is a biologically active homodimer [Elektronski vir]
    Dolenc, Iztok, 1962- ...
    Human cathepsin X belongs to the cathepsin family of 11 lysosomal cysteine proteases. We expressed recombinant procathepsin X in Pichia pastoris in vitro and cleaved it into its active mature form ... using aspartic cathepsin E. We found, using size exclusion chromatography, X-ray crystallography, and small-angle X-ray scattering, that cathepsin X is a biologically active homodimer with a molecular weight of ~53 kDa. The novel finding that cathepsin X is a dimeric protein opens new horizons in the understanding of its function and the underlying pathophysiological mechanisms of various diseases including neurodegenerative disorders in humans.
    Source: Biochimica et biophysica acta. Proteins and proteomics.. - ISSN 1878-1454 (Vol. 1869, iss. 2, 2021, str. 1-10)
    Type of material - e-article
    Publish date - 2021
    Language - english
    COBISS.SI-ID - 42300419

    Link(s):

    https://www.sciencedirect.com/science/article/pii/S1570963920302144?via%3Dihub
    DOI

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