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Reaching toward underexplored targets in antibacterial drug design [Elektronski vir]Jukič, Marko ; Gobec, Stanislav, 1970- ; Sova, Matej, 1979-The increase of antimicrobial resistance necessitates the renewal and strong research involvement in antibacterial drug design. In the following work, we comment on the key approaches used in ... development of new antibacterials, focusing on intracellular therapeutic targets that have been so far mostly underexplored: the enzymes of the Mur pathway MurA to MurF. We identify common obstacles observed during research on MurA, MurB, and Mur ligases inhibitors and their development into potential antibacterial compounds, and discern several approaches and solutions to tackle the whole%cell activity of designed compounds. Furthermore, we consolidate recent literature reports and encourage the further research on Mur enzymes.Source: Drug development research. - ISSN 1098-2299 (Vol. 80, no. 1, 2019, str. 1-5)Type of material - e-articlePublish date - 2019Language - englishCOBISS.SI-ID - 4623217
Author
Jukič, Marko |
Gobec, Stanislav, 1970- |
Sova, Matej, 1979-
Topics
Bakterije |
Bakterijska rezistenca |
Mur ligaze |
MurA |
MurF |
tarčna zdravila
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Jukič, Marko | 32587 |
Gobec, Stanislav, 1970- | 15284 |
Sova, Matej, 1979- | 25490 |
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