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Naravne spojine kot viri spojin vodnic v farmacevtski kemiji = Natural compounds as sources of lead compounds in drug discoveryZidar, NaceSpojine, izolirane iz rastlin, živali in mikrobov, so za zdravljenje ljudi v uporabi že od pradavnine. Uporaba naravnih produktov pri razvoju novih učinkovin je dosegla vrh v letih 1970%1980, v t. i. ... zlati dobi antibiotikov. Kljub nekaterim velikim uspehom so pred nekaj desetletji opazili trend upadanja vpliva naravnih spojin na razvoj novih učinkovin. Za to obstaja več razlogov, med katerimi je zelo pomembna uveljavitev nekaterih novejših tehnologij za odkrivanje učinkovin, kamor sodita kombinatorna kemija in rešetanje visoke zmogljivosti, ki večinoma temeljita na sinteznih kemijskih knjižnicah. Kljub velikim pričakovanjem pa omenjeni pristopi niso prinesli želenih rezultatov, zaradi česar se je v zadnjem obdobju ponovno obudilo zanimanje za naravne spojine, s katerimi bi lahko obogatili raznolikost obstoječih kemijskih knjižnic. Za obujeno zanimanje za naravne spojine je odgovoren tudi razvoj novih tehnologij, ki omogočajo hitrejšo analizo in vrednotenje tudi kompleksnejših naravnih vzorcev.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 69, št. 5, dec. 2018, str. 335-340)Type of material - article, component partPublish date - 2018Language - slovenianCOBISS.SI-ID - 4654705
Author
Zidar, Nace
Topics
Antibiotiki |
biološka aktivnost |
naravna spojina |
odkrivanje učinkovin |
spojina vodnica |
visokozmogljivo rešetanje
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source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 69, št. 5, dec. 2018, str. 335-340)
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Zidar, Nace | 28905 |
Source: Personal bibliographies
and: SICRIS
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