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Efficient synthesis and preliminary biological evaluations of trifluoromethylated imidazo[1,2-a]pyrimidines and benzimidazo[1,2-a]pyrimidinesJismy, Badr ...Fluoromethylated imidazo[1,2-a]pyrimidines and benzimidazo[1,2-a]pyrimidines were synthesized through Michael addition/intramolecular cyclization reaction by condensation of 2-amino imidazole ... derivatives with ethyl 4,4,4-trifluorobut-2-ynoate and using C-O bond activation. The synthons thus obtained can be functionalized by forming new chemical bonds, including C-C, C-N and C-S, to provide easy access to a wide range of novel trifluoromethylated imidazo[1,2-a]pyrimidines and benzimidazo[1,2-a]pyrimidines in good to excellent yields. Preliminary biological evaluation revealed a number of derivatives displaying micromolar IC50 values against monoamine oxidase B and butyrylcholinesterase, two important targets in the field of neurodegenerative disorders.Source: New journal of chemistry. - ISSN 1144-0546 (Vol. 43, iss. 25, 2019, str. 9961-9968)Type of material - article, component part ; adult, seriousPublish date - 2019Language - englishCOBISS.SI-ID - 4738929
Author
Jismy, Badr |
Akssira, Mohamed |
Knez, Damijan, farmacevt |
Guillaumet, Gérald |
Gobec, Stanislav, 1970- |
Abarbri, Mohamed
Topics
Nevrodegenerativne bolezni |
trifluoromethylated imidazo[1,2-a]- pyrimidines |
benzimidazo[1,2-a]pyrimidines |
C-O bond activation |
monoamine oxidase B |
butyrylcholinesterase |
neurodegenerative disorders
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Jismy, Badr | |
Akssira, Mohamed | |
Knez, Damijan, farmacevt | 36438 |
Guillaumet, Gérald | |
Gobec, Stanislav, 1970- | 15284 |
Abarbri, Mohamed |
Source: Personal bibliographies
and: SICRIS
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