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Organoruthenated nitroxoline derivatives impair tumor cell invasion through inhibition of cathepsin B activityMitrović, Ana ...Lysosomal cysteine peptidase cathepsin B (catB) is an important tumor-promoting factor involved in tumor progression and metastasis representing a relevant target for the development of new antitumor ... agents. In the present study, we synthesized 11 ruthenium compounds bearing either the clinical agent nitroxoline that was previously identified as potent selective reversible inhibitor of catB activity or its derivatives. We demonstrated that organoruthenation is a viable strategy for obtaining highly effective and specific inhibitors of catB endo- and exopeptidase activity, as shown using enzyme kinetics and microscale thermophoresis. Furthermore, we showed that the novel metallodrugs by catB inhibition significantly impair processes of tumor progression in in vitro cell based functional assays at low noncytotoxic concentrations. Generally, by using metallodrugs we observed an improvement in catB inhibition, a reduction of extracellular matrix degradation and tumor cell invasion in comparison to free ligands, and a correlation with the reactivity of the monodentate halide leaving ligand.Source: Inorganic chemistry. - ISSN 0020-1669 (Vol. 58, iss. 18, 16 Sep. 2019, str. 12334-12347)Type of material - article, component partPublish date - 2019Language - englishCOBISS.SI-ID - 4769905
Author
Mitrović, Ana |
Kljun, Jakob |
Sosič, Izidor |
Uršič, Matija, kemik |
Meden, Anton |
Gobec, Stanislav, 1970- |
Kos, Janko, 1959- |
Turel, Iztok
Topics
Tumorji |
katepsin B |
cisteinske peptidaze |
eksopeptidaze |
encimska kinetika
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Mitrović, Ana | 36440 |
Kljun, Jakob | 30698 |
Sosič, Izidor | 30816 |
Uršič, Matija, kemik | 37407 |
Meden, Anton | 08790 |
Gobec, Stanislav, 1970- | 15284 |
Kos, Janko, 1959- | 04648 |
Turel, Iztok | 11053 |
Source: Personal bibliographies
and: SICRIS
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