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Magnesium sulfate as tocolytic agent = Magnezijev sulfat kot tokolitik
Franić, Damir ...
The aim of this prospective study was to investigate the properties of magnesium sulfate in pharmacologic inhibition of premature labor (PL). One part of the study included fifteen patients with the ...diagnosis of PL (Protocol "M"), who were treated with ▫$MgSO_4$▫ (1,6 gr/h during 72 h). The other part of the study included ten patients, who were treated with ritodrine(150 mg/500 ml of 5% glucose infusion at a rate of 0,3 mg/ml = 20 drops/min during 72 h) (Protocol "R"). All patients had singleton pregnancies, intact membranes, gestational age 30-36 weeks, cervical changes with Bishop index ▫$\geq$▫4 and/or cervical dilatation ▫$\leq▫$4 cm. There were no material or fetal contraindications for tocolytic therapy. The mean magnesium levels before starting tocolytic therapy was 0,57 mmol/l, which supports the hypothesis, that hypomagnesemia under 0,60 mmol/l migh be a predictor for PL. The mean magnesium level to achieve tocolysis was 1,28 mmol/l. In criterium for successfull tocolysis was the prolongation of pregnancy for more than 72 h. The time needed to achieve tocolytic effect was 18,3 h for ▫$MgSO_4$▫ and 11,8 h for ritodrine. There were two cases of failure in both groups. Side effects were much more alarming in the ritodrine. There were two cases of failure in both groups. Side effects were much more alarming in the ritodrine group than in the ▫$MgSO_4$▫ group, but it was not necessary to stop the tocolysis. ▫$MgSO_4$▫ was found to be a succesful, inexpensive and probably notoxic tocolytic agent, as effective as ritodrine. The dose used in our study was low, but still effective enought to achieve the tocolysis
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