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Efficacy of calcipotriol-betamethasone ointment in patients with mild to moderate plaque psoriasis : subgroup analysesHabjanič, Nina ...Background: Several factors have been shown to affect psoriasis pathogenesis, clinical presentation and treatment response. Objectives: The aim of this study was to investigate the potential ... relationship between patients' baseline characteristics and the efficacy of calcipotriol-betamethasone ointment in patients with mild to moderate plaque psoriasis and to evaluate whether the efficacy is consistent across subgroups. Method: Using data from the therapeutic equivalence study on patients with plaque psoriasis, post hoc analyses were performed to evaluate the impact of baseline demographic and disease characteristics, habits and comorbidities on the response to treatment with calcipotriol-betamethasone ointment. Results: Body mass index (BMI) and obesity were each independently associated (univariate analysis, p < 0.05) with reduction in modified Psoriasis Area and Severity Index (mPASI) and PASI75 (%75% improvement in mPASI from baseline). Increased body weight is more common in patients with late-onset psoriasis. There was a significant trend for lower response rates with increasing BMI (p = 0.007) and obesity (p = 0.003). The odds of achieving PASI75 is 2.3 times lower for obese compared to normal-weight subjects.If patients with obesity or hypertension were treated with calcipotriol-betamethasone, they were still more likely to achieve PASI75 after 4-week treatment compared to vehicle (p < 0.001). Conclusion: Increased BMI and obesity present risk factors for reduced treatment effectiveness. Importantly, the efficacy of calcipotriol-betamethasone ointment was consistent in all subgroups.Source: Dermatology. - ISSN 1018-8665 (Vol. 235, no. 6, Nov. 2019, str. 501-508)Type of material - article, component partPublish date - 2019Language - englishCOBISS.SI-ID - 4786289
Author
Habjanič, Nina |
Lužar - Stiffler, Vesna |
Kerec Kos, Mojca |
Grabnar, Darja
Topics
Luskavica |
kalcipotriol betametazon
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Habjanič, Nina | |
Lužar - Stiffler, Vesna | |
Kerec Kos, Mojca | 20370 |
Grabnar, Darja | 20669 |
Source: Personal bibliographies
and: SICRIS
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