Akademska digitalna zbirka SLovenije - logo
ALL libraries (COBIB.SI union bibliographic/catalogue database)
  • Neuromuscular junction aging [Elektronski vir] : a role for biomarkers and exercise
    Pratt, Jedd ...
    Age-related skeletal muscle degradation known as %sarcopenia% exerts considerable strain on public health systems globally. While the pathogenesis of such atrophy is undoubtedly multifactorial, ... disruption at the neuromuscular junction (NMJ) has recently gained traction as a key explanatory factor. The NMJ, an essential communicatory link between nerve and muscle, undergoes profound changes with advancing age. Ascertaining whether such changes potentiate the onset of sarcopenia would be paramount in facilitating a timely implementation of targeted therapeutic strategies. Hence, there is a growing level of importance to further substantiate the effects of age on NMJs, in parallel with developing measures to attenuate such changes. As such, this review aimed to establish the current standpoint on age-related NMJ deterioration and consequences for skeletal muscle, while illuminating a role for biomarkers and exercise in ameliorating these alterations. Recent insights into the importance of key biomarkers for NMJ stability are provided, while the stimulative benefits of exercise in preserving NMJ function are demonstrated. Further elucidation of the diagnostic and prognostic relevance of biomarkers, coupled with the therapeutic benefits of regular exercise may be crucial in combating age-related NMJ and skeletal muscle degradation.
    Source: The journals of gerontology. Series A, Biological sciences and medical sciences. - ISSN 1758-535X (Vol. 76, no. 4, Apr. 2021, str. 576-585)
    Type of material - e-article ; adult, serious
    Publish date - 2021
    Language - english
    COBISS.SI-ID - 50759939

    Link(s):

    https://academic.oup.com/biomedgerontology/advance-article-abstract/doi/10.1093/gerona/glaa207/5896490?redirectedFrom=fulltext
    DOI

Shelf entry