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  • Variability of anti-human transglutaminase testing in celiac disease across Mediterranean countries [Elektronski vir]
    Smarrazzo, Andrea ...
    AIM: To verify the precision and accuracy of transglutaminase antibodies (TGA) assays across Mediterranean countries. METHODS: This study involved 8 referral centres for celiac disease (CD) in 7 ... Mediterranean countries. A central laboratory prepared 8 kits of 7 blinded and randomized serum samples, with a titrated amount of Human TGA IgA. Each sample was analysed three times on three different days, with each centre running a total of 21 tests. The results were included in a blindly coded report form, which was sent to the coordinator centre. The coordinator estimated the mean coefficient of Variation (CoVar = %/%), the mean accuracy (Accur = Vobserved - Vreal) and the mean percent variation (Var% = [(Vobserved - Vreal)/Vreal] % 100). RESULTS: The analysis showed that 79.17% of the mean variation fell between -25% and +25% of the expected value, with the accuracy and precision progressively increasing with higher titres of TGA. From values 1.25 times greater than the normal cut-off, the measurements were highly reliable. CONCLUSION: TGA estimation is a crucial step for the diagnosis of CD; given its accuracy and precision, clinicians could be confident in establishing a diagnosis.
    Source: World journal of gastroenterology [Elektronski vir]. - ISSN 2219-2840 (Vol. 23, iss. 24, 2017, str. 4437-4443)
    Type of material - e-article
    Publish date - 2017
    Language - english
    COBISS.SI-ID - 512879928

    Link(s):

    https://f6publishing.blob.core.windows.net/69324007-1723-428e-b2fc-edd8b829b046/WJG-23-4437.pdf
    DOI

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