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Gene electrotransfer of proinflammatory chemokines CCL5 and CCL17 as a novel approach of modifying cytokine expression profile in the tumor microenvironmentBožič, Tim, 1993- ...The effectiveness of immunotherapy highly correlates with the degree and the type of infiltrated immune cells in the tumor tissue. Treatments based on modifying the immune cell infiltrate of the ... tumor microenvironment are thus gaining momentum. Therefore, the aim of our study was to investigate the effects of gene therapy with two proinflammatory chemokines CCL5 and CCL17 on inflammatory cytokine expression profile and immune cell infiltrate in two murine breast tumor models, 4T1 and E0771, and two murine colon tumor models, CT26 and MC38. In vitro, lipofection of plasmid DNA encoding CCL5 or CCL17 resulted in changes in the cytokine expression profile similar to control plasmid DNA, implying that the main driver of these changes was the entry of foreign DNA into the cell%s cytosol. In vivo, gene electrotransfer resulted in high expression levels of both Ccl5 and Ccl17 transgenes in the 4T1 and CT26 tumor models. Besides a minor increase in the survival of the treated mice, the therapy also resulted in increased expression of Cxcl9 and Ifn%, potent activators of the immune system, in CT26 tumors. However, this was not recapitulated in changes of TME, implying that a further refinement of the dosing schedule is needed.Source: Bioelectrochemistry. - ISSN 1567-5394 (Vol. 140, 2021, str. 1-107795-13-107795)Type of material - article, component partPublish date - 2021Language - englishCOBISS.SI-ID - 55465219
Author
Božič, Tim, 1993- |
Serša, Gregor |
Kranjc Brezar, Simona |
Čemažar, Maja |
Markelc, Boštjan
Topics
kemokini |
citokinsko izražanje |
genski elektroprenos |
CCL5 |
chemokines |
cytokine expression |
gene electrotransfer |
CCL5
Author | Božič, Tim, 1993- ... |
Title | Gene electrotransfer of proinflammatory chemokines CCL5 and CCL17 as a novel approach of modifying cytokine expression profile in the tumor microenvironment |
Publication date | 2021-03-09 |
COBISS.SI-ID | 55465219 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Spremljanje imunskega odziva v realnem času po in situ vakcinaciji z elektrokemoterapijo in pridruženo gensko terapijo z interlevkinom-12 | J3-8202-2017 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Razvoj in ovrednotenje novih terapij za zdravljenje malignih tumorjev | P3-0003-2015 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Files that belong to the publication
Link |
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https://dirros.openscience.si/IzpisGradiva.php?id=15560 |
Costs of publication
Cost type | Total cost | Payments |
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APC – Article Processing Charge | 1744.60 € |
1744.60 € : Onkološki inštitut Ljubljana |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Božič, Tim, 1993- | 51848 |
Serša, Gregor | 08800 |
Kranjc Brezar, Simona | 19058 |
Čemažar, Maja | 14575 |
Markelc, Boštjan | 32175 |
Source: Personal bibliographies
and: SICRIS
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