ALL libraries (COBIB.SI union bibliographic/catalogue database)
-
Effects of L-dopa on expression of prolactin and synaptotagmin IV in 17[beta]-estradiol-induced prolactinomas of ovariectomized hemiparkinsonian rats [Elektronski vir]Zorović, Maja ; Kolmančič, Kaja ; Živin, Marko, 1958-Parkinson's disease (PD) is a long - term degenerative disorder of the central nervous system that mainly affects the motor system. Dopamine precursor L - dopa is used as the first - line treatment ... for PD. Evidence suggests neuroprotective effects of estrogens in PD. Since both E2 and L - dopa act as regulators of prolactin secretion from the pituitary gland, we investigated their effect on the expression of prolactin (PRL) in prolactinomas that developed in ovariectomized hemiparkinsonian rats treated with 17b - estradiol (E2). We also inv estigated the effect of E2 and L - dopa on the expression of synaptotagmin IV (Syt IV), an immediate early gene whose product is abundant in the pituitary gland and was found to be highly co - expressed with PRL in lactotrophs (> 90%). The hemiparkinsonian rat model was obtained by unilateral lesioning of dopaminergic nigrostriatal neurons. Rats received silastic tubing implants with E2 and were treated with L - dopa. ELISA and immunohistochemistry were used to assess the serum concentrations of PRL and E2 and ex pression of PRL and SytIV in the tissue of adenohypophysis, respectively. We found that high levels of serum 17b - estradiol were associated with the upregulation of Syt IV and PRL in PRL - ir cells, while treatment with L - dopa decreased the size of prolactino mas and downregulated Syt IV but had no effect on PRL expression or serum concentrations.Source: Bosnian journal of basic medical sciences [Elektronski vir]. - ISSN 1840-4812 (Vol. 21, no. 6, 2021, str. 701-710)Type of material - e-article ; adult, seriousPublish date - 2021Language - englishCOBISS.SI-ID - 58461955
Author
Zorović, Maja |
Kolmančič, Kaja |
Živin, Marko, 1958-
Topics
Parkinson's disease |
estradiol |
prolactin |
Parkinsonova bolezen |
estradiol |
prolaktin
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Zorović, Maja | 21503 |
Kolmančič, Kaja | 38242 |
Živin, Marko, 1958- | 08289 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: