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Prihodnost : farmakogenomika zdravilKaras Kuželički, NatašaGlavni namen farmakogenomike je prilagoditi terapijo z zdravili posameznemu bolniku z namenom optimizacije varnosti in učinkovitosti terapije. Pri implementaciji farmakogenomike v klinično prakso so ... primarnega pomena smernice za uporabo farmakogenetskih markerjev pri prilagoditvi terapije, ki jih izdajata Dutch Pharmacogenetics Working Group (DPWG) in Clinical Pharmacogenetic Implementation Consortium (CPIC). DPWG je sestavila seznam genov in polimorfizmov z velikim kliničnim vplivom na odziv na pogosto predpisovana zdravila (PGx Passport). Le-ta obsega 58 variantnih alelov v 14 genih, ki vplivajo na odziv na 49 pogosto uporabljenih zdravil. V zadnjem desetletju se je razmahnilo farmakogenetsko testiranje prek spleta. Glavna kritika stroke glede takšnega testiranja temelji na odsotnosti strokovnjakov pri svetovanju in razlagi rezultatov testiranja, poleg tega se kriteriji za vključitev polimorfizmov in genov v testni panel pri spletnih ponudnikih razlikujejo od vključitvenih kriterijev DPWG in CPIC. V prihodnosti bodo imeli lekarniški farmacevti pomembno vlogo kot vmesni člen med uporabniki in ponudniki farmakogenetskih testiranj prek spleta. Čeprav so raziskave pokazale, da imajo lekarniški farmacevti večinoma pozitiven odnos do farmakogenetskega testiranja, pa se jih večina ne čuti kompetentnih za interpretacijo rezultatov tovrstnega testiranja. V sled navedenemu je treba poskrbeti za ustrezno izobraževanje na tem področju tako za bodoče kot že aktivne lekarniške farmacevte.Source: Samotestiranje, hitro testiranje ali testiranje ob preiskovancu? : strokovno izpopolnjevanje s področja farmacije : [Ljubljana, 15., 16. in 22. junij 2021] (Str. 95-105)Type of material - conference contributionPublish date - 2021Language - slovenianCOBISS.SI-ID - 67819523
Author
Karas Kuželički, Nataša
Topics
Funkcijska genomika |
Testi |
Zdravila |
farmakogenomika
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Karas Kuželički, Nataša | 21459 |
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