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Vpliv sestave in mletja kompaktatov na sproščanje karvedilola iz ogrodnih tablet s hipromelozo = Effects of ribbons composition and milling on the release of carvedilol from hypromellose-based matrix tablets : enoviti magistrski študijski program FarmacijaŽagar, Tjaša, farmacevtkaUporaba ogrodnih sistemov kot nosilcev prirejenega sproščanja je zaradi številnih prednosti v porastu. V ta namen se najpogosteje uporablja hipromeloza (HPMC), ki ima ob stiku z vodnimi raztopinami ... visoko sposobnost tvorbe gela. V okviru magistrske naloge smo pripravili ogrodne tablete s hipromelozo in karvedilolom kot modelno zdravilno učinkovino. Z valjčnim kompaktiranjem smo iz praškaste zmesi pripravili kompaktate sestavljene iz različnih polnil. Kompaktate smo po izdelavi mleli z različnimi vrstami mlinov pri izbranih procesnih parametrih mletja, nastale granule pa tabletirali v ogrodne tablete. Preveriti smo želeli, ali in kako razlike v vrsti uporabljenega polnila ter načinu mletja kompaktatov vplivajo na fizikalne in partikulatne lastnosti granul in sproščanje zdravilne učinkovine iz končne farmacevtske oblike. Na velikost granul najbolj vpliva izbira mlina za mletje, poleg tega pa je velikost granul odvisna tudi od velikosti odprtin uporabljene mreže. Nakazuje se tudi vpliv vrste uporabljenega polnila. Na sproščanje karvedilola iz ogrodnih tablet s hipromelozo vplivata vrsta uporabljenega mlina ter uporabljeno polnilo, pri čemer je vpliv vrste uporabljenega mlina preko vpliva na velikost granul izrazitejši v začetnem delu profila sproščanja, po vzpostavitvi gelskega plašča pa začne prevladovati vpliv uporabljenega polnila.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [T. Žagar], 2021Language - slovenianCOBISS.SI-ID - 69379587
Author
Žagar, Tjaša, farmacevtka
Other authors
Vrečer, Franc |
Hudovornik, Grega, farmacevt
Topics
Farmacevtske oblike |
Farmavcetska tehnologija |
kompaktiranje |
mletje |
velikost granul |
sproščanje učinkovin |
ogrodne tablete |
vrsta polnila
Library/institution |
City | Acronym | For loan | Other holdings |
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Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Žagar, Tjaša, farmacevtka | |
Vrečer, Franc | 08333 |
Hudovornik, Grega, farmacevt | 32217 |
Source: Personal bibliographies
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