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  • Purine adducts as a presumable missing link for aristolochic acid nephropathy related cellular energy crisis, potential anti-fibrotic prevention and treatment [Elektronski vir]
    Kocić, Gordana ...
    Aristolochic acid nephropathy (AAN) is a progressive exposome-induced disease characterized by tubular atrophy and fibrosis culminating in end-stage renal disease and malignancies. The molecular ... mechanisms of the energy crisis as a putative cause of fibrosis have not yet been elucidated. In light of the fact that aristolochic acid (AA) forms DNA and RNA adducts by covalent binding of AA metabolites to exocyclic amino groups of (deoxy)adenosine and (deoxy)guanosine, we hypothesize here that similar AA adducts may exist with other purine-containing molecules. We also provide new insights into the AA-induced energy crisis and presumably a link between already known mechanisms. In addition, an overview of potential targets in fibrosis treatment is provided, which is followed by recommendations on possible preventive measures that could be taken to at least postpone or partially alleviate AAN.
    Source: British journal of pharmacology [Elektronski vir]. - ISSN 1476-5381 (Vol. 178, no. 22, 2021, str. 4411-4427)
    Type of material - e-article ; adult, serious
    Publish date - 2021
    Language - english
    COBISS.SI-ID - 69769219

    Link(s):

    https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15618
    DOI

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