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  • Improved survival after breast-conserving therapy compared with mastectomy in stage I-IIA breast cancer [Elektronski vir]
    Ratoša, Ivica ...
    In the current study, we sought to compare survival outcomes after breast-conserving therapy (BCT) or mastectomy alone in patients with stage I-IIA breast cancer, whose tumors are typically suitable ... for both locoregional treatments. The study cohort consisted of 1360 patients with stage I-IIA (T1%2N0 or T0%1N1) breast cancer diagnosed between 2001 and 2013 and treated with either BCT (n = 1021, 75.1%) or mastectomy alone (n = 339, 24.9%). Median follow-ups for disease-free survival (DFS) and overall survival (OS) were 6.9 years (range, 0.3%15.9) and 7.5 years (range, 0.2%25.9), respectively. Fifteen (1.1%), 14 (1.0%) and 48 (3.5%) patients experienced local, regional, and distant relapse, respectively. For the whole cohort of patients, the estimated 5-year DFS and OS were 96% and 97%, respectively. After stratification based on the type of local treatment, the estimated 5-year DFS for BCT was 97%, while it was 91% (p < 0.001) for mastectomy-only treatment. Inverse probability of treatment weighting matching based on confounding confirmed that mastectomy was associated with worse DFS (HR 2.839, 95% CI 1.760%4.579, p < 0.0001), but not with OS (HR 1.455, 95% CI 0.844%2.511, p = 0.177). In our study, BCT was shown to have improved disease-specific outcomes compared to mastectomy alone, emphasizing the important role of adjuvant treatments, including postoperative radiation therapy, in patients with early-stage breast cancer at diagnosis.
    Source: Cancers [Elektronski vir]. - ISSN 2072-6694 (Vol. 13, iss. 16, 2021, str. 4044-1-4044-15)
    Type of material - e-article
    Publish date - 2021
    Language - english
    COBISS.SI-ID - 72894723

    Link(s):

    https://www.mdpi.com/2072-6694/13/16/4044
    DOI

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