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Vzpostavitev modelnega sistema za določanje imunomodulatornih lastnosti mlečnokislinskih bakterij na celični liniji THP-1 = A THP-1 cell line-based model system setup for testing immunomodulatory properties of lactic acid bacteria : University Study Programme CosmetologyRepar, LaraMlečnokislinske bakterije so grampozitivne bakterije, ki imajo podobne fiziološke in metabolne lastnosti. Uporabljajo se predvsem v živilski industriji, pri proizvodnji fermentiranih izdelkov, ter v ... farmacevtski industriji kot dostavni in ekspresijski sistemi. Zaradi ugodnih učinkov na zdravje gostitelja številne mlečnokislinske bakterije uvrščamo med probiotike. Različne študije so pokazale, da mlečnokislinske bakterije sprožijo aktivacijo monocitov, spodbudijo izločanje citokinov in vplivajo na delovanje drugih imunskih celic. Učinki mlečnokislinskih bakterij so zelo raznoliki in odvisni od vrste ter seva bakterije, zato je izbira ustrezne bakterije ključnega pomena za uspešnost študije. Teste in vitro uporabljamo za iskanje kandidatov z ustreznimi imunomodulatornimi lastnostmi. V okviru diplomske naloge smo določali porast izločanja vnetnega citokina interlevkina 8 po izpostavitvi celic THP-1 inaktiviranim modelnim mlečnokislinskim bakterijam. Citokine izločajo številne imunske celice pod vplivom različnih dražljajev, kot so bakterijski endotoksini. Kot modelno mlečnokislinsko bakterijo smo uporabili Lactococcus lactis, ki smo jo inaktivirali z izpostavitvijo ultravijoličnemu valovanju. Porast izločanja citokina smo merili z encimsko-imunskim testom (ELISA) in količino izločenega interlevkina 8 primerjali z izločanjem po tretiranju celic THP-1 z bakterijo Escherichia coli, ki nam je služila za kontrolo. Kot model za primarne monocite smo uporabili celično linijo THP-1, ki se običajno uporablja za določanja dejavnosti monocitov in makrofagov v študijah in vitro. Vzpostavili smo test za določanje vpliva mlečnokislinskih bakterij na izločanje interlevkina 8 iz celične linije THP-1. Potrdili smo, da inaktivirana Lactococcu lactis modulira izločanje interlevkina 8 iz monocitne celične linije THP-1.Type of material - undergraduate thesis ; adult, seriousPublication and manufacture - Ljubljana : [L. Repar], 2021Language - slovenianCOBISS.SI-ID - 75909379
Author
Repar, Lara
Other authors
Lunder, Mojca, 1977-
Topics
Imunomodulatorji |
Mlečnokislinske bakterije |
Citokini |
mlečnokislinske bakterije |
Lactococcus lactis |
interlevkin 8 |
celična linija THP-1
Library/institution |
City | Acronym | For loan | Other holdings |
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Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Repar, Lara | |
Lunder, Mojca, 1977- | 25096 |
Source: Personal bibliographies
and: SICRIS
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