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Klinični pomen protijedrnih protiteles pri vezivnotkivnih boleznihPahor, Artur ...Protijedrna protitelesa so pogosto prisotna pri vezivnotkivnih boleznih. Predstavljamo skupino 279 neselekcioniranih bolnikov z vezivnotkivnimi boleznimi, vnetnimi in degenerativnimi sklepnimi ... boleznimi, kroničnimi infekcijskimi boleznimi in rakastimi boleznimi ter nekaterimi nejasnimi patološkimi stanji pri katerih smo v serumu zasledili pozitivna protijedrna protitelesa. Pregledali smo tip imunofluorescence in prisotnost ekstraktibilnih protijedrnih protiteles (ENA). Pri sistemskem lupus eritematosusu prevladuje homogeni (H) tip imunofluorescence (60,6%); protitelesa proti Ro/SS-A antigenu so prisotna v 24,2%, proti Sm in proti RNP pa v 12,1%. Pri Sjögren-ovem sindromu prevladuje grudasti (S) tip imunofluorescence (47,6%); protitelesa proti Ro/SS-A in proti La/SS-B antigenu so prisotna v 52,4%, samo proti Ro/SS-A pa v 28,6%. Tip S imunofluorescence prevladuje v sistemski sklerozi v 37,5% in v 75% je prisotno protitelo proti Scl-70. Pri mešanih boleznih vezivnega tkiva je protitelo proti RNP prisotno v 85,7%. Pri dermato-polimiozitisu je protitelo proti Jo-1 prisotno v 33,3%. Tip S imunofluorescence je prisoten pri 70% bolnikov z nediferencialno boleznijo vezivnega tkiva. Pri revmatoidnem artritisu prevladuje imunofluorescenca tipa H (46,4%) in tip S (41,0%), medtem ko je prisotnost ENA redka (proti Ro/SS-A v 4,6%). Najpogosteje pri spondilartritisih opazujemo tip S imunofluorescence (62,5%). Bolniki s kroničnimi infekcijskimi boleznimi, rakastimi boleznimi, nedefiniranimi stanji ali z degenerativnimi stanji ali z degenerativnimi sklepnimi boleznimi imajo različne tipe imunofluorescence; prisotnost ENA pa je izjemno redka pri teh bolnikih. Rezultati te raziskave pokažejo pomen protijedrnih protiteles in še posebej ENA v diagnostiki vezivnotkivnih bolezni. Ta protitelesa pa so lahko tudi prisotna pri bolnikih z različnimi infekcijskimi in rakastimi boleznimi, kot tudi pri vnetnih in degenerativnih sklepnih boleznih.Source: Interna medicina 2001 - novosti in aktualnosti : zbornik predavanj 1. kongresa Združenja internistov SZD, Ljubljana, 27. - 29. september 2001 (str. 337-343)Type of material - conference contribution ; adult, seriousPublish date - 2001Language - slovenianCOBISS.SI-ID - 763455
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Database name | Field | Year |
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Krajnc, Ivan, 1948- | 02053 |
Gorenjak, Maksimiljan | 07616 |
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