ALL libraries (COBIB.SI union bibliographic/catalogue database)
13.
Application of commercially available mesoporous silica for drug dissolution enhancement in oral drug delivery
Baumgartner, Ana ; Planinšek, Odon
Due to the high number of poorly water-soluble active pharmaceutical ingredients, oral drug delivery development has become challenging. One of the strategies to enhance drug solubility and to ...achieve high oral bioavailability is to formulate such compounds into amorphous solid dispersions. In recent years, porous materials have been investigated as possible carriers into which a drug can be adsorbed, such as mesoporous silica, in particular. Unlike the ordered mesoporous network of silica, non-ordered silica already has a ''generally regarded as safe'' status, and is already used as an excipient in pharmaceutical and cosmetic products. Thus, it is reasonable to expect that products that contain solid dispersions with non-ordered carriers will reach the market sooner and more easily than those with ordered mesoporous carriers. The emphasis of this review is therefore on non-ordered commercially available mesoporous silica and the progress that has been made in development of the use of these materials for improved dissolution rates in oral drug delivery. First, a thorough categorisation of the drug loading methods is presented, followed by discussion on the most important characteristics of solid dispersions (i.e., physical state, stability, drug release). Finally, manufacturability and production of a final solid dosage form are considered.
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
