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Retrospektivna analiza zaznanih različic hemoglobina v Univerzitetnem kliničnem bolnišničnem centru Zagreb v obdobju od 2018 do 2020 = Retrospective analysis of hemoglobin variants detected at the University Clinical Hospital Centre Zagreb from 2018 to 2020 : magistrski študijski program Laboratorijska biomedicinaTeskera, MirnaZ izrazom hemoglobinopatije označujemo skupino bolezni, povezanih z motnjami sinteze globina, ki s hemom tvori strukturo molekule hemoglobina (Hb). Prvi korak pri diagnosticiranju hemoglobinopatije ... je hemoglobinski test. Izvajamo ga z elektroforezo Hb, s katero določamo prisotnost njegovih različic v testiranih vzorcih. V okviru magistrske naloge smo želeli prikazati primerjavo opravljenih elektroforeznih testov hemoglobina in števila z njimi zaznanih različic tekom vsakega meseca v obdobju od januarja 2018 do decembra 2020. Skupno smo retrospektivno analizirali 1061 elektroforeznih profilov hemoglobina, in sicer 312 iz leta 2018, 455 iz leta 2019 in 294 iz leta 2020. Od vseh analiziranih rezultatov, jih je bilo 24,4% izven referenčnega intervala. Med pregledom rezultatov smo naleteli na različne variante Hb: S, E, D, Lepore ter naše rezultate predstavili s pomočjo slik, ki jih je generiral aparat, s katerim so bile izvedene analize. Odkrite različice so povezane z nekaterimi boleznimi. Med temi je najbolj znana anemija srpastih celic zaradi prisotnosti variante HbS. Danes imamo na voljo tudi test za odkrivanje potencialnih nosilcev genov za hemoglobinopatije, ki so predvsem podedovane motnje, poleg tega pa lahko testiramo že plod, da bi ugotovili, ali je prizadet s hemoglobinopatijo. Čeprav gre za redke bolezni, jih je treba spremljati, saj v zadnjem času zaradi povečanega števila migracij in podeljenih azilov v evropskih državah prihaja do povečane pojavnosti hemoglobinopatij.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [M. Teskera], 2021Language - slovenianCOBISS.SI-ID - 78078211
Author
Teskera, Mirna
Other authors
Jeras, Matjaž |
Šegulja, Dragana
Topics
Klinična kemija |
hemoglobin |
hemoglobinopatija |
različice hemoglobina |
elektroforeza |
sinteza hemoglobina
Library/institution |
City | Acronym | For loan | Other holdings |
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Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Teskera, Mirna | |
Jeras, Matjaž | 01302 |
Šegulja, Dragana |
Source: Personal bibliographies
and: SICRIS
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