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Mapping brain-behavior space relationships along the psychosis spectrumJi, Jie Lisa ...Difficulties in advancing effective patient-specific therapies for psychiatric disorders highlights a need to develop a neurobiologically-grounded, quantitatively stable mapping between neural and ... symptom variation. This gap is particularly acute for psychosis-spectrum disorders (PSD). Here, in a sample of 436 cross-diagnostic PSD patients, we derived and replicated a data-driven dimensionality-reduced symptom space across hallmark psychopathology symptoms and cognitive deficits, which was predictive at the single patient level. In turn, these data-reduced symptom axes mapped onto distinct and replicable univariate brain maps. Critically, we found that multivariate brain-behavior mapping techniques (e.g. canonical correlation analysis) did not show stable results. Instead, we show that a univariate brain-behavioral space (BBS) mapping can resolve stable individualized prediction. Finally, we show a proof-of-principle framework for relating personalized BBS metrics with molecular targets via serotonin and glutamate receptor manipulations and gene expression maps. Collectively, these results highlight a stable and data-driven BBS mapping across PSD, which offers an actionable quantitative path that can be iteratively optimized for personalized clinical biomarker endpoints.Type of material - offprint ; adult, seriousPublication and manufacture - Cambridge : Life Sciences, 2021Language - englishCOBISS.SI-ID - 78202627
Author
Ji, Jie Lisa |
Helmer, Markus |
Fonteneau, Clara |
Burt, Joshua B. |
Tamayo, Zailyn |
Demšar, Jure, računalničar |
Adkinson, Brendan D. |
Savic, Aleksandar |
Preller, Katrin H. |
Moujaes, Flora |
Vollenweider, Franz X. |
Martin, William J., genetik |
Repovš, Grega |
Murray, John D., nevroznanstvenik |
Anticevic, Alan
Topics
nevroznanost |
možgani |
psihoza |
simptomi |
izražanje genov |
slikanje možganov |
kartografija možganov |
izbira bolnikov |
separati |
neurosciences |
brain |
psychosis |
symptoms |
gene expression |
neuroimaging |
brain mapping |
patient selection |
offprints
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Faculty of Arts, Central Humanities Library, Lj. | Ljubljana | FFLJ |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Ji, Jie Lisa | ![]() |
Helmer, Markus | ![]() |
Fonteneau, Clara | ![]() |
Burt, Joshua B. | ![]() |
Tamayo, Zailyn | ![]() |
Demšar, Jure, računalničar | 37645 |
Adkinson, Brendan D. | ![]() |
Savic, Aleksandar | ![]() |
Preller, Katrin H. | ![]() |
Moujaes, Flora | ![]() |
Vollenweider, Franz X. | ![]() |
Martin, William J., genetik | ![]() |
Repovš, Grega | 17893 |
Murray, John D., nevroznanstvenik | ![]() |
Anticevic, Alan | ![]() |
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