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Vplivi zaviralcev dihidrofolat reduktaze in sulfametoksazola na delovanje z AMP-aktivirane protein kinaze v kulturah človeških in podganjih skeletnomišičnih celic = Effects of dihydrofolate reductase inhibitors and sulfamethoxazole on AMP-activated protein kinase in cultured human and rat skeletal muscle cells : enoviti magistrski študij farmacija
Šutar, Mateja
Z AMP aktivirana protein kinaza (AMPK) je osrednji energijski senzor na ravni celice in organizma ter obetavna tarča v terapiji presnovnih motenj. Raziskave kažejo, da metotreksat, zaviralec ...dihidrofolat reduktaze, in sulfanilamid sulfasalazin lahko vplivata na aktivnost AMPK v skeletni mišici. Mehanizem delovanja je inhibicija encima ATIC (5-amino-4-imidazolkarboksamid ribonukleotid formiltransferaza/inozin monofosfat ciklohidrolaza). S tem se upočasni presnova ZMP, ki je fosforilirana oblika AICAR, farmakološkega aktivatorja AMPK. Tako se zmanjša prag za z AICAR spodbujeno AMPK aktivacijo. Posledično se v celici povečata privzem glukoze in lipidna oksidacija, kar zmanjša hiperglikemijo in inzulinsko rezistenco pri osebah s sladkorno boleznijo tipa 2. Namen naloge je bil proučiti, ali na delovanje AMPK v skeletni mišici poleg metotreksata in sulfasalazina vplivajo tudi nekateri drugi klinično uporabni zaviralci dihidrofolat reduktaze (trimetreksat in trimetoprim) oziroma sulfanilamidi, kot je sulfametoksazol, ki se uporablja skupaj s trimetoprimom.
Type of material - master's thesis
; adult, serious
Publication and manufacture - Ljubljana : [M. Šutar], 2021
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