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Early glottic cancer : the influence of primary therapy on ultimate organ preservation
Lešničar, Hotimir ; Šmid, Alojz, 1941- ; Zakotnik, Branko
To achieve better comparison of final treatment results between 44 primarily operated and 219 primarily irradiated patients with early glottic cancer, retrospective identification of patients based ...on criteria of suitability for voice-sparing operation was made. In patients, found to be suitable for organ preservation surgery 10-years disease specific survival (DSS) of 94% vs. 92% in T1 and 94% vs. 87% in T2 tumors was estimated for primarily operated and irradiated patients reseptively (p=0.1). If the over-all treatment time in primary irradiated patients was shorter than 48 days, final preservation of larynx was achieved in 97% and was identical with the primary surgery group. In patients with T2 tumors unsuitable for voice-sparing operation significantly lower 10-years DSS, namely 71% vs. 65%, for primary surgery and radiotherapy respectively was found. If treated with primary surgery all thesepatients would have nedeed total laryngectomy, however with primary radiotherapy with over-all treatment time shorter than 48 days, the final preservation of voice succeded in 87% of patients.
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