ALL libraries (COBIB.SI union bibliographic/catalogue database)
-
Povezanost izbranih polimorfizmov v genu za XRCC6 s hitrostjo napredovanja kronične limfocitne levkemije = Association of selected polymorphisms in XRCC6 gene with progression of chronic lymphocytic leukemia : enoviti magistrski študijski program FarmacijaŠtor, JernejaPolimorfizmi v bližini regulatornih delov gena XRCC6 so povezani z večjim tveganjem za pojav rakavih obolenj, kamor prištevamo tudi KLL. Večjo pojavnost rakavih obolenj so v azijski populaciji ... zaznali pri nosilcih alela G pri rs2267437 ter nosilcih alela C pri rs5751129. Namen magistrskega dela je bil ugotoviti, ali pojavnost določenih alelov/genotipov predstavlja napovedni dejavnik tveganja za slovensko populacijo bolnikov s KLL. Iz polne krvi bolnikov s KLL (N = 233) in kontrolne skupine (N = 121) smo izolirali DNA in z uporabo hidrolizirajočih sond TaqMan® določili genotipe za XRCC6 rs2267437 in XRCC6 rs5751129. V drugem sklopu smo preučevali vpliv genotipa ter kliničnih podatkov na hitrost napredovanja KLL, prikazanih kot čas, ki preteče od diagnoze do uvedbe terapije. V analizo preživetja po Kaplan – Meierju smo vključili 144 bolnikov s KLL. Rezultati magistrske naloge kažejo, da sta rs2267437 in rs5751129 v slovenski kohorti bolnikov in zdravih posameznikov v skladu s HW ravnotežjem. Med rizičnim alelom G (p = 0,6705) oz. rizičnima genotipoma CG in GG (p = 0,51) pri rs2267437 in rizičnim alelom C (p = 1,00) oz. rizičnima genotipoma CT in CC (p = 1,00) pri rs5751129 ter večjim tveganjem za pojav KLL v slovenski populaciji ni povezave, zato se le-ti ne morejo uporabiti kot napovedni dejavniki tveganja. Pojavnost polimorfizmov v slovenski populaciji se razlikuje od azijske populacije (p rs2267437 < 0,0001, p rs5751129 = 0,04), kjer obstaja povezava med genotipom in večjim tveganjem za pojav rakavih obolenj, ne razlikuje pa se od evropske (p rs2267437 = 0,67, p rs5751129 = 1,00), kjer tovrstne povezave niso dokazali. Ugotovili smo, da ni razlik v razporeditvi alelov (p rs2267437 = 0,48 p rs5751129 = 0,38) ali genotipov (p rs2267437 = 1,00, p rs5751129 = 0,14) med moškimi in ženskimi bolniki KLL. Nadalje smo ugotovili, da rizična genotipa CG in GG pri rs2267437 (p dominantni model = 0,58, p recesivni model = 0,51) in rizična genotipa CC in CT pri rs5751129 (p dominantni model = 0,34, p recesivni model = 0,44) ne vplivata na hitrejši potek bolezni pri bolnikih s KLL. Spol ne vpliva na hitrost napredovanja bolezni pri bolnikih s KLL (p = 0,41). Bolniki z neugodnimi citogenetskimi preureditvami; del(11q22) in del(17q13) imajo hitrejši potek bolezni napram bolnikom z ugodnimi citogenetskimi preureditvami (p = 0,016). Bolniki v stadiju B ali C po Binetu imajo hitrejši potek bolezni napram tistim v stadiju A (p < 0,0001).Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [J. Štor], 2021Language - slovenianCOBISS.SI-ID - 89643523
Library/institution |
City | Acronym | For loan | Other holdings |
---|---|---|---|---|
Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
|
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Štor, Jerneja | |
Šmid, Alenka, farmacevtka | 29982 |
Markovič, Tijana | 34223 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: