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Growth hormone insensitivity syndromes: a preliminary report on changes in insulin-like growth factors and their binding proteins during treatment with recombinant insulin-like growth factor IBlum, W... F. ...Serum levels of insulin-like growth factor (IGF) binding proteins (IGFBPs) 1, 2 and 3 were studied by radioimmunoassay in 29 patients with growth hormone (GH) insensitivity syndromes (GHIS) before ... and during treatment with IGF-I. Asin normal subjects, there was a highly significant correlation between IGFs and IGFBP-3 but not between IGFs and the other binding proteins, though IGFBP-3 represented only about one-third of the total IGFBP concentration. In 6 patients with GH deficiency and in 5 patients with GHIS, the pharmacokineticprofile of IGF-I after a single injection was strongly dependent on the IGFBP-3 concentrations. A slight but significant increase in IGFBP-3 was observed coincident with the IGF-I peak, whereas IGFBP-2 inceased after a delay of about 10 hours. In the patients with GHIS, chronic IGF-I treatment, with twice-daily injections for 6 months, caused a significant steady decline of IGF-II and an increase in IGFBP-2, but had no effect on IGFBP-1 and IGFBP-3 levels. During IGF-I treatment, an inverse relationship between baseline IGF-I and GH levels was observed. The data suggest that totalIGF-I and IGF-II serum levels are determined mainly by IGFBP-3, even in extreme situations such as GHIS, while other IGFBPs are less important. The IGFBP-3 concentration seems to be a major regulator of the pharmacokinetics ofexogenous IGF-I, which, in turn, influences IGFBP-3 levels. This effect of IGF-I on IGFBP-3 is not through induction of IGFBP-3 synthesis, but possibly by reduction of IGFBP-3 clearance. Finally, IGF-I administration suppresses GHsecretion.Source: Acta paediatrica. - ISSN 0803-5253 (Suppl. 391, 1993, str. 15-19)Type of material - article, component partPublish date - 1993Language - englishCOBISS.SI-ID - 9701849
Author
Blum, W... F. |
Hall, K... |
Ranke, M... B. |
Wilton, P... |
Kržišnik, Ciril, 1944-2024
Topics
Dwarfism |
Drug therapy |
Blood |
Insulin-like growth factor i |
Therapeutic use |
Pharmacology |
Receptors, somatotropin |
Deficiency |
Somatomedins |
Adolescence |
Adult |
Child |
Insulin-like growth factor ii |
Pharmacokinetics |
Models, biological |
Recombinant proteins |
Therapeutic use |
Pharmacokinetics |
Somatotropin |
Deficiency
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Kržišnik, Ciril, 1944-2024 | 02278 |
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