National Institute of Biology and BF, Department of Biology, Ljubljana - all departments (BFBNIB)
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Virus hepatitisa G pri bolnikih z velikim tveganjem okužbe : diplomska naloga = Hepatitis G virus infection among patients at high risk for infection : graduation thesisFatur, TanjaLeta 1995 so osamili RNA novo odkritega virusa, ki so ga poimenovali virus hepatitisa G (HGV). Odkrili so, da se virus prenaša s krvjo, vendar do sedaj še ni znano, če HGV povzroča katero bolezen. Z ... našo študijo smo želeli ugotoviti prevalenco HGV v Sloveniji. Okužbo s HGV lahko določamo na posreden in na neposreden način. Na neposreden način, smo z reverzno transkripcijo in verižno reakcijo s polimerazo (Boehringer Mannheim, Nemčija) dokazovali prisotnost RNA HGV v serumskih vzorcih. Na posreden način, smo z encimsko imunskim testom (Boehringer Mannheim, Nemčija) določali prisotnost nastalih protiteles proti beljakovini virusne ovojnice E2, anti-E2. Kot skupino zdravega prebivalstva z majhno možnostjo okužbe, smo izbrali serumske vzorce 40 nosečnic. V nobenem serumskem vzorcu nismo dokazali RNA HGV, v 5 % vzorcev smo dokazali anti-E2. V treh rizičnih skupinah smo odkrili višjo prevalenco HGV. Pregledali smo serumske vyorce 40 bolnikov s kroničnim hepatitisom C in v 10 % odkrili RNA HGV, v 20 % smo odkrili anti-E2. 6.7 % serumskih vyorcev od pregledanih 15 hemofilikov je RNA HGV pozitivnih. 46.7 % hemofilikov je anti-E2 pozitivnih. V 80 serumskih vzorcih intravenskih uživalcev drog smo v 15.4 % dokazali prisotnost RNA HGV, v 42.5 % pregledanih vzorcev smo ugotovili protitelesa anti-E2. V naši študiji smo ugotovili, da je prevalenca HGV v Sloveniji nižja kot v nekaterih drugih državah, kjer so že opravili podobne raziskave. Ugotovili smo tudi, da je potrebno prevalenco HGV določati na osnovi RNA HGV in anti-E2.Type of material - undergraduate thesis ; adult, seriousPublication and manufacture - Ljubljana : [T. Fatur] ; [BF, Enota medoddelčnega študija mikrobiologije], 1998Language - slovenianCOBISS.SI-ID - 2077816
Author
Fatur, Tanja
Other authors
Poljak, Mario, 1965-
Topics
virusi |
virus hepatitisa G |
HGV |
prevalenca HGV |
RT-PCR |
anti-E2 |
anti-E2 |
viruses |
hepatitis G virus |
HGV |
HGV prevalence |
RT-PCR |
anti-E2 |
anti-E2
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Fatur, Tanja | 19157 |
Poljak, Mario, 1965- | 11622 |
Source: Personal bibliographies
and: SICRIS
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