Faculty of Pharmacy, Lj. (FFALJ)
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Vpliv klinično-biokemičnih parametrov za farmakokinetiko tramadola = Influence of clinical-biochemical parameters on pharmacokinetics of tramadol : diplomska nalogaAntolič, RokTramadol, ki je strukturno blizu morfinu in kodeinu, je centralno delujoè analgetik, ki ima dvojni mehanizem delovanja. Po eni strani gre njegov uèinek na raèun vezave na receptorje v centralnem ... zivèevju, po drugi strani pa na raèun zavore ponovnega privzema noradrenalina in serotonina v presinaptiène zivène konèièe. Indikacije za uporabo tramadola so zmerne in zmerno hude boleèine. V nasprotju z drugimi opioidi ne povzroèa depresije dihanja in pomembneje ne vpliva na srènozilni sistem. Tramadol je bazièna uèinkovina, ki se absorbira v alkalnem okolju tankega èrevesja. Presnavlja se v jetrih in ob tem nastane aktivni metabolit O-desmetiltramadol. Eliminacija poteka preko ledvic in zolèa.Namen dela je bil ugotoviti vpliv hematoloskih parametrov, koncentracije kreatinina in celokupnih beljakovin v plazmi na nekatere farmakokinetiène parametre tramadola pri zdravih prostovoljcih. Ugotovili smo znatno interindividualno variabilnost farmakokinetiènih parametrov po enkratniperoralni aplikaciji 100 mg tramadola pri zdravih moskih prostovoljcih.Nasi rezultati kazejo, da moramo del te variabilnosti pripisati lastnosti tramadola, da se veze inžali prehaja v eritrocite, saj veèji hematokrit zagotavlja veè prostora za distribucijo tramadola. Ustrezno se poveèa eliminacija tramadola iz plazme, zmanjsa se AUC ter Cmax in tmax. Torejlahko fizioloske razlike v hematokritu, pa tudi stevilu eritrocitov in hemoglobinu, znatno vplivajo na variabilnost kljuènih farmakokinetiènih parametrov kot so AUC, Vd, Cmax in kel. To zahteva skrben izbor zdravih prostovoljcev pri vkljuèevanju v farmakokinetiène raziskave s tramadolom in predvidoma tudi drugimi zdravili (npr. dihidropiridinskimi antagonisti kalcija). Ni namreè moè zanemariti dejstva, da so lahko vzrok za nepredvidljiv farmakokinetièni farmakodinamski odgovor na tramadol tudi razlike v stopnji vezave inžali vstopanja v eritocite.Type of material - undergraduate thesisPublication and manufacture - Ljubljana : [Antolič R.], 2003Language - slovenianCOBISS.SI-ID - 1386097
Author
Antolič, Rok
Other authors
Kozjek, Franc
Topics
bolečina |
tramadol |
farmakokinetika |
indikacije |
interakcije |
statistične metode
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Knjižnica dp 0000000615 Antolič, Rok Vpli IN: 0006989 Knjižnica dp 615 Antolič, Rok Vpli IN: 0006989 |
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Antolič, Rok | |
Kozjek, Franc | 00184 |
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