Faculty of Pharmacy, Lj. (FFALJ)
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Poskus osamitve adenovirusov iz zgornjih in spodnjih dihal otrok z nepojasnjeno obstruktivno pljučno boleznijo = An attempt to isolate adenoviruses from upper and lower respiratory tract of children with unexplained obstructive pulmonary disease : diplomska nalogaRade, MarijaOd prvega odkritja adenovirusov leta 1953 pa do danes so pri ljudeh osamili 51serotipov. Ti virusi so razsirjeni po vsem svetu, bolezni, ki jih povzroèajo, pa so zelo razliène in se pojavljajo preko ... vsega leta. Vkljuèujejookuzbe dihal, prebavil, seèil, oèi, centralnega zivènega sistema ter koze in obièajno izzvenijo brez veèjih posledic. Priblizno 50 % okuzb poteka brez simptomov, inkubacijska doba pa traja 4 do 5 dni. Znano je, da adenovirusni genom lahko vztraja v pljuènih celicah in izraza proteine se dolgo po poteku akutne okuzbe. Virus namreè lahko svoj genom ali del genoma vgradi v gostiteljske celice epitelija dihal in domnevno prispeva k nastanku kroniène obstruktivne pljuène bolezni.V bronhoalveolarnih lavatih, brisih nosnozrelnega prostora in aspiratih 27 otrok smo s poskusom osamitve adenovirusov na celicah Vero v mikrotitrski plosèici z 48 vdolbinicami dokazovali infektivne viruse. Identificirali smo jih z monoklonskimi protitelesi. Predhodno so s to metodo v laboratoriju za diagnostiko virusnih okuzb ze dokazovali antigene adenovirusov neposredno v kuznini. Nasa hipoteza je bila, da bomo vsaj iz nekaj kuznin osamili adenoviruse. S hitro metodo smo osamili virus le iz treh od 53-tih kuznin (5,7 %). Nizko stevilo pozitivnih rezultatov verjetno pomeni, da v èasu odvzema veèina otrok v dihalih ni imela infektivnega virusa, niti virusnih antigenov. Hitra metoda, ki smo jo uporabili za osamitev virusov, se je izkazala za primerno, saj je dovolj obèutljiva in ekonomsko ter èasovno varèna, zato je primerna tudi za redno diagnostièno dejavnost. Predvsem je tu pomemben èasovni vidik. Pri klasièni metodi je namreè za osamitev virusa potrebnih priblizno 5 dni, medtem ko smo shitro metodo potrdili infektivne adenonoviruse po dveh do treh dneh. Krajsi èas, v katerem pridemo do rezultatov, je pomemben predvsem za nadaljevanje primernega protivirusnega zdravljenja in za prekinitev nepotrebnega protibakterijskega zdravljenja ter za èimhitrejso osamitev okuzenih bolnikov.Type of material - undergraduate thesisPublication and manufacture - Ljubljana : [Rade, M.], 2005Language - slovenianCOBISS.SI-ID - 1799537
Author
Rade, Marija
Other authors
Marin, Jožica
Topics
adenovirusi |
patogeneza |
preprečevanje okužb |
zdravljenje |
diagnostika
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Knjižnica dp 0000000616 Rade Marija Poskus IN: 0008498 Knjižnica dp 616 Rade Marija Poskus IN: 0008498 |
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Rade, Marija | ![]() |
Marin, Jožica | 03172 |
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