Faculty of Pharmacy, Lj. (FFALJ)
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Ugotavljanje povezanosti treh polimorfizmov v genu PPARG s sindromom policističnih jajčnikov = Association between three polymorphisms in PPARG gene and polycystic ovary syndrome : diplomska nalogaLevstik, TomažSindrom policistiènih jajènikov (PCOS) je endokrina motnja, ki prizadene 5-10%zensk vseh ras in narodnosti. Klinièno se kaze kot hiperandrogenizem in kronièna anovulacija. Je najpogostejsa hormonska ... motnja med zenskami v rodni dobi in vodilni razlog za zensko neplodnost. Simptomi in njihova jakost se medbolnicami moèno razlikujejo. Etiologija PCOS je multifaktorska in poligenska. Velik delez bolnic ima inzulinsko rezistenco (IR). Inzulinska rezistenca oznaèuje stanje z zmanjsano odzivnostjo tkiv na inzulin, ki lahko nastane na katerikoli stopnji inzulinskega signaliziranja. Predvidevajo, da jeeden od pomembnih dejavnikov kroniènih obolenj, kot so sladkorna bolezen tipa 2, kardiovaskularna obolenja in PCOS. S peroksisomskim proliferatorjem aktiviran receptor (PPAR ) je jedrni receptor, ki igra kljuèno vlogo pri metabolizmu lipidov, regulira izrazanje genov za proteine, odgovorne za privzem PMK in je nujno potreben za diferenciacijo in prezivetje adipocitov. Agonisti PPAR - tiazolidindioni izboljsajo obèutljivost tkiv na inzulin in lipidemièni profil pacientov z diabetesom tipa 2. V nasi studiji smo preiskovali povezanost toèkovnih polimorfizmov -681C>G (rs10865710), Pro12Ala (rs1801282) in -689C>T (rs7649970) v genu PPARG s kliniènimi in biokemiènimi kazalci IR in PCOS na populaciji 134 bolnic s PCOS in 107 zdravihpreiskovank. DNA preiskovank smo pomnozili z verizno reakcijo s polimerazo in jo genotipizirali z analizo polimorfizmov dolzin restrikcijskihfragmentov. Ugotovili smo, da se genotipske in alelne frekvence za posamezen polimorfizem med bolnicami s PCOS ter zdravimi preiskovankami znaèilno ne razlikujejo. Alel 12Ala je bil znaèilno povezan z nizjo plazemsko glukozo na tesèe. Alel -689T je bil mejno znaèilno povezan z visjimi vrednostmi LH in nizjimi vrednostmi FSH, kar poveèuje tveganje za pojav PCOS. Oba alela sta bila nakazano povezana z nizjimi serumskimi koncentracijami SHBG, kar ima za posledico moènejse delovanje androgenov na tkiva in favorizira razvoj PCOS. Preuèevani polimorfizmi so v vezalnem neravnovesju. Diplotip, ki ima na obeh kromosomih mutiran alel -681G, ima glede na nemutirandiplotip znaèilno visji plazemski FSH in s tem manjse tveganje za pojav hormonskih motenj, povezanih s PCOS.Type of material - undergraduate thesisPublication and manufacture - Ljubljana : [T. Levstik], 2007Language - slovenianCOBISS.SI-ID - 2132081
Author
Levstik, Tomaž
Other authors
Marc, Janja |
Mlinar, Barbara, 1974-
Topics
policistični jajčniki |
PPAR |
patofiziologija |
polimeraza |
analiza polimorfizmov |
zdravljenje
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Knjižnica dp 0000000615 Levstik Tomaž Ugotavljanje IN: 0009519 Knjižnica dp 615 Levstik Tomaž Ugotavljanje IN: 0009519 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Levstik, Tomaž | |
Marc, Janja | 12189 |
Mlinar, Barbara, 1974- | 18996 |
Source: Personal bibliographies
and: SICRIS
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