Faculty of Pharmacy, Lj. (FFALJ)
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Vpliv formulacije na permeabilnost učinkovin skozi celični model dihalnega epitelija = Influence of formulation on the drug permeability through a cell model of the respiratory epithelium : magistrski študijski program Laboratorijska biomedicinaDraškovič, TinaNosna aplikacija velja za neinvaziven in preprost način dostave učinkovin, s katero se izognemo metabolizmu prvega prehoda peroralno apliciranih zdravil. Pri napovedovanju in vitro-in vivo korelacij ... imajo pomembno vlogo in vitro celični modeli, ki so uporabna in etična metoda za preučevanje načinov transporta, študije permeabilnosti in toksičnosti spojin. Namen našega dela je bil izmeriti permeabilnost nekaterih učinkovin za lokalno zdravljenje nosne sluznice v apikalno-bazolateralni smeri in ovrednotiti vpliv formulacije na njihovo permeabilnost. Kot model nosnega epitelija smo uporabili celični liniji RPMI 2650 in Calu-3 nosnega in pljučnega izvora. Ob gojenju na meji med zrakom in tekočino tvorita tesen epitelij, ki sovpada s karakteristikami humanega nosnega epitelija. Celice smo gojili po optimiziranem postopku na polprepustnih membranah. Rast celic smo spremljali pod invertnim svetlobnim mikroskopom. Ustrezno integriteto celičnega sloja smo potrdili z merjenjem transepitelijske električne upornosti ter prehajanjem paracelularnega označevalca lucifer rumeno. Izmerjeno permeabilnost smo izrazili z navideznim koeficientom permeabilnosti (Papp). Dokazali smo, da ob enaki sestavi formulacije dostavni sistem (npr. kapljice in pršilo za nos) ne vpliva na permeabilnost. Potrdili smo, da jakost zdravila v enakem vehiklu za učinkovine s pasivnim transportom ne vpliva na permeabilnost. S primerjavo netretiranih formulacij z redčenimi formulacijami, standardnimi raztopinami in drugimi formulacijami smo pokazali vpliv formulacije na permeabilnost. Ob razredčitvi raztopin je prišlo do zmanjšanja koncentracije učinkovine in pomožnih snovi, kar lahko privede do upada ali dviga permeabilnosti. Pokazali smo, da je obseg absorpcije učinkovin nižji, kadar so učinkovine v obliki suspenzije, kot v obliki raztopine. Preiskovane spojine smo klasificirali kot dobro ali slabo permeabilne in dokazali, da nimajo toksičnega učinka na respiratorna celična modela.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [T. Draškovič], 2020Language - slovenianCOBISS.SI-ID - 28332547
Author
Draškovič, Tina
Other authors
Žakelj, Simon, 1976- |
Kristan, Katja, 1975-
Topics
Dostavni sistemi |
celični model RPMI 2650 |
celični model Calu-3 |
dihalni epitelij |
permeabilnost |
nosne formulacije |
pBCS |
citotoksičnost
Call number – location, accession no. ... |
Copy status | Reservation |
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Knjižnica mlab 0000000615 DRAŠKOVIČ TINA Vpliv 0000000234 IN: 0016691 Knjižnica mlab 615 DRAŠKOVIČ TINA Vpliv 234 IN: 0016691 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Draškovič, Tina | |
Žakelj, Simon, 1976- | 22659 |
Kristan, Katja, 1975- | 24392 |
Source: Personal bibliographies
and: SICRIS
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