Faculty of Pharmacy, Lj. (FFALJ)
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PGE(2)-driven induction and maintenance of cancer-associated myeloid-derived suppressor cellsObermajer, Nataša ...Myeloid-derived suppressor cells (MDSCs) are critical mediators of tumor-associated immune suppression, with their numbers and activity strongly increased in most human cancers and animal models. ... MDSCs suppress anti-tumor immunity through multiple mechanisms, including the manipulation of arginine and tryptophan metabolism by such factors as arginase (Arg), inducible nitric oxide synthase (iNOS/NOS2), and indoleamine-2,3-dioxygenase (IDO). Prostaglandin E2 (PGE2), a mediator of chronic inflammation and tumor progression, has emerged as a key molecule in MDSC biology. PGE2 promotes MDSC development and their induction by additional factors, directly suppresses T cell immune responses and participates in the induction of other MDSC-associated suppressive factors, including Arg, iNOS and IDO. It further promotes MDSC recruitment to tumor environments through the local induction ofCXCL12/SDF-1 and the induction and stabilization of the CXCL12 receptor, CXCR4, on tumor-associated MDSCs. The establishment of a positive feedback loop between PGE2 and cyclooxygenase 2 (COX-2), the key regulator of PGE2 synthesis, stabilizes the MDSC phenotype and is required for their suppressive function. The central role of PGE2 in MDSC biology provides for a feasible target for counteracting MDSC-mediated immune suppression in cancer.Source: Immunological investigations. - ISSN 0882-0139 (Vol. 41, no. 6-7, 2012, str. 635-657)Type of material - article, component partPublish date - 2012Language - englishCOBISS.SI-ID - 3316337
Author
Obermajer, Nataša |
Wong, Jeffrey L. |
Edwards, Robert P. |
Odunsi, Kunle |
Moysich, Kirsten |
Kalinski, Pawel
Topics
PGE2 |
toleranca |
prostaglandini |
imunopatologija |
imunoterapija |
rak |
vnetje |
dentritične celice
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Obermajer, Nataša | 25494 |
Wong, Jeffrey L. | |
Edwards, Robert P. | |
Odunsi, Kunle | |
Moysich, Kirsten | |
Kalinski, Pawel |
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