Faculty of Pharmacy, Lj. (FFALJ)
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Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathwayJakopin, ŽigaDysregulation of nucleotide-binding oligomerization domains 1 and 2 (NOD1 and NOD2) has been implicated in the pathology of various inflammatory disorders, rendering them and their downstream ... signaling proteins potential therapeutic targets. Selective inhibition of NOD1 and NOD2 signaling could be advantageous in treating many acute and chronic diseases, therefore harnessing the full potential of NOD inhibitors is a key topic in medicinal chemistry. Although they are among the best studied NOD-like receptors (NLRs), the therapeutic potential of pharmacological modulation of NOD1 and NOD2 is largely unexplored. This review is focused on the scientific progress in the field of NOD inhibitors over the past decade, including the recently reported selective inhibitors of NOD1 and NOD2. In addition, all known and potential approaches to inhibition of NOD signaling are covered. The advantages and disadvantages linked with inhibition of NOD signaling and potential directions for drug discovery are also discussed.Source: Journal of medicinal chemistry. - ISSN 0022-2623 (Vol. 57, issue 16, 2014, str. 6897-6918)Type of material - article, component part ; adult, seriousPublish date - 2014Language - englishCOBISS.SI-ID - 3630705
Author
Jakopin, Žiga
Topics
NOD1 inhibitor |
NOD2 inhibitor |
NF-[kappa]B inhibition |
NOD signaling |
inflammatory diseases
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Jakopin, Žiga | 26496 |
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