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Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and ß-amyloid aggregation inhibitors with neuroprotective propertiesGuzior, Natalia ...The presented study describes the synthesis, pharmacological evaluation (AChE and BuChE inhibition, beta amyloid anti-aggregation effect and neuroprotective effect), molecular modeling and ... crystallographic studies of a novel series of isoindoline-1,3-dione derivatives. The target compounds were designed as dual binding site acetylcholinesterase inhibitors with an arylalkylamine moiety binding at the catalytic site of the enzyme and connected via an alkyl chain to a heterocyclic fragment, capable of binding at the peripheral anionic site of AChE. Among these molecules, compound 15b was found to be the most potent and selective AChE inhibitor (IC50EeAChE = 0.034 microM). Moreover, compound 13b in addition to AChE inhibition (IC50 EeAChE = 0.219 microM) possesses additional properties, such as the ability to inhibit Aßaggregation (65.96% at 10 microM) and a neuroprotective effect against Aß toxicity at 1 and 3 microM. Compound 13b emerges as a promising multi-target ligand for the further development of the therapy for age-related neurodegenerative disorders.Source: European journal of medicinal chemistry. - ISSN 0223-5234 (Vol. 92, 2015, str. 738-749)Type of material - article, component part ; adult, seriousPublish date - 2015Language - englishCOBISS.SI-ID - 3806577
Author
Guzior, Natalia |
Bajda, Marek |
Skrok, Mirosław |
Kurpiewska, Katarzyna |
Lewiński, Krzysztof |
Brus, Boris |
Pišlar, Anja |
Kos, Janko, 1959- |
Gobec, Stanislav, 1970- |
Malawska, Barbara
Topics
Alzheimerjeva bolezen |
medicinska kemija |
zaviralci holinesteraz |
multitarčni ligandi |
ß-amiloidni zaviralci |
nevrodegenerativne bolezni |
cholinesterase inhibitors |
ß-amyloid aggregation inhibitors |
neuroprotection |
Alzheimerʼs disease |
multi-target-directed ligands
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Guzior, Natalia | ![]() |
Bajda, Marek | ![]() |
Skrok, Mirosław | ![]() |
Kurpiewska, Katarzyna | ![]() |
Lewiński, Krzysztof | ![]() |
Brus, Boris | 34508 |
Pišlar, Anja | 32035 |
Kos, Janko, 1959- | 04648 |
Gobec, Stanislav, 1970- | 15284 |
Malawska, Barbara | ![]() |
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