Faculty of Pharmacy, Lj. (FFALJ)
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Kartiranje epitopov monoklonskih in poliklonskih protiteles proti protrombinu = Epitope mapping of polyclonal and monoclonal antiprothrombin antibodies : univerzitetni študijski program KozmetologijaJud, LauraAntifosfolipidni sindrom je sistemska avtoimunska bolezen posredovana z antifosfolipidnimi protitelesi, za katero so značilne venske in arterijske tromboze različnih segmentov obtočil ter zapleti v ... nosečnosti. V heterogeno skupino antifosfolipidnih protiteles sodijo protitelesa usmerjena proti različnim plazemskim proteinom, ki se v serumu bolnikov določajo s specifičnimi imunskimi testi ali testi koagulacije. V diplomski nalogi smo se osredotočili na protitelesa proti protrombinu z namenom določitve njihovega vezavnega mesta na protrombinu. Z metodo bakteriofagnega prikaza smo iz knjižice dodekapeptidov, izraženih na bakteriofagih, izvedli selekcijo bakteriofagov, ki so izkazovali vezavo na izolirana protitelesa proti protrombinu. Izolirane bakteriofage smo ovrednotili s testom ELISA, izbranim fagom smo izolirali DNA ter jim določili aminokislinsko zaporedje peptidov, predstavljenih na površini teh klonov. Dobljena aminokislinska zaporedja dodekapeptidov smo nato prilegali na terciarno strukturo protrombina. Določili smo štiri različne motive peptidov, dva motiva peptidov, ki smo jih pridobili v selekciji na poliklonskih protitelesih (eden od teh se je pojavil v predhodnih študijah) in dva motiva peptidov, ki smo jih pridobili v selekciji na monoklonskih protitelesih. S prileganjem peptidov na kristalne strukture protrombina smo predvideli epitopska mesta. Prišli smo do zaključka, da konformacija protrombina pomembno vpliva na katero domeno se bodo vezala protitelesa. Pri zviti konformaciji protrombina (4O03) smo z algoritmom predvideli epitope na domeni serinske proteaze in domeni >>kringle<<-2, medtem ko je algoritem enake peptide na nezvito obliko protrombina (6BJR in 4NZQ) prilegal na različne domene.Type of material - undergraduate thesis ; adult, seriousPublication and manufacture - Ljubljana : [L. Jud], 2019Language - slovenianCOBISS.SI-ID - 4779377
Author
Jud, Laura
Other authors
Lunder, Mojca, 1977- |
Žigon, Polona, 1978-
Topics
Avtoimunske bolezni |
protitelesa proti protrombinu |
metoda bakteriofagnega prikaza |
kartiranje epitopov |
protrombin
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Knjižnica UNK 0000000616 JUD LAURA Kartiranje 0000000166 IN: 0016284 Knjižnica UNK 616 JUD LAURA Kartiranje 166 IN: 0016284 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Jud, Laura | ![]() |
Lunder, Mojca, 1977- | 25096 |
Žigon, Polona, 1978- | 24206 |
Source: Personal bibliographies
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