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  • Poly-L-lysine as an effective and safe desquamation inducer of urinary bladder epithelium [Elektronski vir]
    Kerec Kos, Mojca ; Veranič, Peter ; Erman, Andreja
    Induced desquamation of urinary bladder epithelial cells, also called urothelial cells, is frequently used in studies of bladder epithelial regeneration and also in treating recurrent bacterial ... cystitis. Positively charged polymer chitosan is known to cause large-scale desquamation of terminally differentiated urothelial cells called umbrella cells. Aiming to compare the desquamation ability of another polycation poly-L-lysine, we studied the effect of this polymer on the functional and structural integrity of the urothelium in ex vivo and in vivo experiments. The urothelium was analyzed by measuring transepithelial electrical resistance, and the structural changes of its luminal surface were analyzed with scanning electron microscopy. The results revealed a selective and concentration-dependent desquamation effect of poly-L-lysine on superficial urothelial cells followed by quick regeneration of the urothelium, which functionally and structurally recovers in 2 to 3 h after poly-L-lysine-induced injury. Poly-L-lysine was thus proven to be a promising polymer to be used when desquamation of urothelial cells is required in basic and potentially clinical studies.
    Source: Polymers [Elektronski vir]. - ISSN 2073-4360 (Vol. 11, iss. 9, 2019, str. 1-14)
    Type of material - e-article ; adult, serious
    Publish date - 2019
    Language - english
    COBISS.SI-ID - 4789617

    Link(s):

    https://www.mdpi.com/search?q=&authors=kerec+kos&journal=polymers&article_type=&search=Search&section=&special_issue=&volume=&issue=&number=&page=

    Prost dostop


    https://www.mdpi.com/2073-4360/11/9/1506
    Repository of the University of Ljubljana – RUL
    DOI

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