Razvoj metode za ugotavljanje znotrajceličnih koncentracij izbranih zaviralcev imunoproteasoma psolarenskega tipa na osnovi tekočinske kromatografije ultra visoke ločljivosti = Development of an ultra-high-performance liquid chromatography method for determination of intracellular concentrations of selected psolaren-based immunoproteasome inhibitors : enoviti magistrski študijski program Farmacija
Debevc, Špela, farmacevtka
Immunoproteasom je znotrajcelična proteaza, katere glavna fiziološka funkcija je, da razgrajuje nepravilno zvite in poškodovane proteine. Zaviranje proteolitične aktivnosti imunoproteasoma bi lahko ...bilo ugodno pri zdravljenju nekaterih rakavih obolenj oz. avtoimunih bolezni. Izbrani zaviralci imunoproteasoma niso izkazovali predvidenega učinka na celični liniji, za kar je lahko kriva premajhna znotrajcelična koncentracija zaviralca. Izbrani zaviralci so namreč zelo lipofilni in ker gre za kovalentne zaviralce, lahko tudi reagirajo s proteini v celičnem mediju. V magistrski nalogi bomo poizkusili razviti metodo na osnovi UHPLC za ugotavljanje intracelularne koncentracije izbranih zaviralcev.
Type of material - master's thesis
; adult, serious
Publication and manufacture - Ljubljana : [Š. Debevc], 2019
Knjižnica emšf 0000000543 DEBEVC ŠPELA Razvoj 0000000803 IN: 0016443
Knjižnica emšf 543 DEBEVC ŠPELA Razvoj 803 IN: 0016443
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