Expert knowledge inclusion in pharmacokinetical models
Belič, Aleš ...
Measurements in biological tissues and liquids are often problematic. Ethical,physical, and financial limitations do not allow many samples to be taken from living organisms and thus precious ...information on system dynamics is not avalability. At the same time accuracy and stability of measurement methods is rather poor in compare to technical sciences. To eliminate noise from the data and to reconstruct the time course of the system dynamics, splines can be used. The time course is determined from expert knowledge and sampled data by using weighted least square method for spline fitting. Weights of data points are determined by the expert. The time cours described by splines, instead of raw masurements, is now used in modelling preocedures. In this work the approach was tested on two substances, histamine and paracetamol. Such procedure showed substantial advantage in the process of determination of model parameters.
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