Library of Technical Faculties, Maribor (KTFMB)
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Biocatalytic response of multi-layer assembled collagen/hyaluronic acid nanoengineered capsulesSousa, Fernanda de ...Biodegradable hollow capsules filled with fluorescently labelled bovine serum albumin (BSA) as a model drug were prepared via layer-by-layer (LbL) self-assembly of type-I collagen (COL) and ... hyaluronic acid (HA) using calcium carbonate micro-particles and co-precipitation method. Capsules loaded with fluorescein isothiocyanate (FITC)-BSA, tetramethylrhodamin isothiocyanate (TRITC)-BSA or Alex-Fluor-488-BSA, respectively, were characterised before and after core removal using Confocal Laser Scanning Microscopy (CLSM), whilst the morphologies of individual hollow capsules were assessed using Atomic Force Microscopy (AFM). The sustained release of the encapsulated FITC-BSA protein was attained using enzymatic degradation of the capsule shells by collagenase. The released profile of the fluorescently-labelled BSA indicated that it could be successfully controlled by modulating the number of layers and/or by collagen crosslinking either before or after the capsuleʼs assembly.Source: Journal of microencapsulation. - ISSN 0265-2048 (Vol. 31, No. 3, 2014, str. 270-276)Type of material - article, component partPublish date - 2014Language - englishCOBISS.SI-ID - 17228310
Author
Sousa, Fernanda de |
Kreft, Oliver |
Sukhorukov, Gleb B. |
Möhwald, Helmuth |
Kokol, Vanja
Topics
kolagen |
kolagenaza |
dostavnost zdravil |
hiauluronska kislina |
collagen |
collagenase |
degradation |
drug delivery |
hyaluoronic acid |
LbL capsules
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Sousa, Fernanda de | |
Kreft, Oliver | |
Sukhorukov, Gleb B. | |
Möhwald, Helmuth | |
Kokol, Vanja | 15322 |
Source: Personal bibliographies
and: SICRIS
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