Zdravljenje akutne venske tromboze = Treatment of acute deep venous thrombosis
Vene, Nina
Early treatment of venous thrombosis is very important as most complications, such as pulmonary embolism, recurrent venous thrombosis and bleeding, occur inthe early period. Until recently, the ...standard treatment for patients with venous thromboembolism was in hospital, with continuous intravenous infusion or subcutaneous injections of unfractionated heparin, and monitoring using theactivated partial thromboplastin time. Lately, low molecular weight heparin, which has many advantages over unfractionated heparin, has changed the treatment of venous thrombosis dramatically. Its increased bioavailabilityand prolonged half-life permit once or twice daily subcutaneousinjections and dosage based on body weight without the need for laboratory monitoring. The treatment of venous thrombosis with low molecular weight heparin is as effective and safe as treatment with unfractionated heparin, with a lower incidence of heparin-induced thrombocytopenia and probably also of osteoporosis. The simple use of the drug has provided an opportunity for initial treatment of venous thrombosis to be performed outsidehospitals. In a carefull selected group of patients and a well organised outpatient facility, such treatment is safe and effective.
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